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The use of natural products to promote health is as old as human civilization. In recent years, the perception of natural products derived from plants as abundant sources of biologically active compounds has driven their exploitation towards the search for new chemical products that can lead to further pharmaceutical formulations. Candida fungi, being opportunistic pathogens, increase their virulence by acquiring resistance to conventional antimicrobials, triggering diseases, especially in immunosuppressed hosts. They are also pointed to as the main pathogens responsible for most fungal infections of the oral cavity. This increased resistance to conventional synthetic antimicrobials has driven the search for new molecules present in plant extracts, which have been widely explored as alternative agents in the prevention and treatment of infections. This review aims to provide a critical view and scope of the in vitro antimicrobial and antibiofilm activity of several medicinal plants, revealing species with inhibition/reduction effects on the biofilm formed by Candida spp. in the oral cavity. The most promising plant extracts in fighting oral biofilm, given their high capacity to reduce it to low concentrations were the essential oils extracted from Allium sativum L., Cinnamomum zeylanicum Blume. and Cymbopogon citratus (DC) Stapf.
The use of natural products to promote health is as old as human civilization. In recent years, the perception of natural products derived from plants as abundant sources of biologically active compounds has driven their exploitation towards the search for new chemical products that can lead to further pharmaceutical formulations. Candida fungi, being opportunistic pathogens, increase their virulence by acquiring resistance to conventional antimicrobials, triggering diseases, especially in immunosuppressed hosts. They are also pointed to as the main pathogens responsible for most fungal infections of the oral cavity. This increased resistance to conventional synthetic antimicrobials has driven the search for new molecules present in plant extracts, which have been widely explored as alternative agents in the prevention and treatment of infections. This review aims to provide a critical view and scope of the in vitro antimicrobial and antibiofilm activity of several medicinal plants, revealing species with inhibition/reduction effects on the biofilm formed by Candida spp. in the oral cavity. The most promising plant extracts in fighting oral biofilm, given their high capacity to reduce it to low concentrations were the essential oils extracted from Allium sativum L., Cinnamomum zeylanicum Blume. and Cymbopogon citratus (DC) Stapf.
Background: Endodontic infections caused by many bacterial species including Staphylococcus aureus, Klebsiella pneumonia and Salmonella enterica present a significant challenge in dental health. Accurate identification of these pathogens is crucial for effective treatment strategies. Aims and Objectives: The aim of the study was to utilize 16S rRNA genotypic analysis for the precise identification of certain bacterial strains isolated from endodontic infected tissues. Materials and Methods: Tissue samples were collected from patients with persistent endodontic infections and microbial cultures were prepared. Strains were isolated, purified. DNA extraction was performed and 16S rRNA gene amplification was carried out using polymerase chain reaction. Subsequently, the amplicons were sequenced and the sequences were compared with known reference sequences using bioinformatics programs. Phylogenetic analysis was conducted to ascertain the evolutionary relationships between the identified isolates and known strains. Results: To our knowledge, this is the first report focusing on genotypic identification of endodontic bacteria from Berhampur, Odisha, India. This study holds implications for species specific microbial ecology in dental infections facilitating quicker identification. Conclusion: Management strategies for endodontic infections may involve a systematic approach to identify, analyze and address the specific challenges such as diagnosis and endodontic emergencies, presented by each case. Focused and individualized treatment plans shall contribute to better clinical outcomes. Further detailed records can be maintained with genotype based treatment plan followed by post treatment outcomes to guide future decisions and research.
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