Review: Embryonic stem cells as tools for in vitro gamete production in livestock

Goszczynski, Daniel Estanislao; Navarro, Marc; Mutto, A.; Ross, Pablo J.

doi:10.1016/j.animal.2023.100828

Cited by 5 publications

(1 citation statement)

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“…Research has discovered a dual role of OSNs in the regulation of pluripotency maintenance. On the one hand, they can act as transcription factors involved in DNA methylation and histone modifications, such as histone methylation and acetylation [ 44 ]. That is to say, OSN transcription factors can maintain the high expression level of genes involved in the maintenance of pluripotency and inhibit the expression of genes related to the promotion of cellular differentiation by altering the epigenetic modification status of the target.…”

Section: Mechanism Of Pluripotency Maintenance Of Escsmentioning

confidence: 99%

Mechanisms of Embryonic Stem Cell Pluripotency Maintenance and Their Application in Livestock and Poultry Breeding

Wang,

Gong,

Yao

et al. 2024

Animals

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Embryonic stem cells (ESCs) are remarkably undifferentiated cells that originate from the inner cell mass of the blastocyst. They possess the ability to self-renew and differentiate into multiple cell types, making them invaluable in diverse applications such as disease modeling and the creation of transgenic animals. In recent years, as agricultural practices have evolved from traditional to biological breeding, it has become clear that pluripotent stem cells (PSCs), either ESCs or induced pluripotent stem cells (iPSCs), are optimal for continually screening suitable cellular materials. However, the technologies for long-term in vitro culture or establishment of cell lines for PSCs in livestock are still immature, and research progress is uneven, which poses challenges for the application of PSCs in various fields. The establishment of a robust in vitro system for these cells is critically dependent on understanding their pluripotency maintenance mechanisms. It is believed that the combined effects of pluripotent transcription factors, pivotal signaling pathways, and epigenetic regulation contribute to maintaining their pluripotent state, forming a comprehensive regulatory network. This article will delve into the primary mechanisms underlying the maintenance of pluripotency in PSCs and elaborate on the applications of PSCs in the field of livestock.

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Section: Mechanism Of Pluripotency Maintenance Of Escsmentioning

confidence: 99%