Review: Cancer and neurodevelopmental disorders: multi-scale reasoning and computational guide
Ruth Nussinov,
Bengi Ruken Yavuz,
Habibe Cansu Demirel
et al.
Abstract:The connection and causality between cancer and neurodevelopmental disorders have been puzzling. How can the same cellular pathways, proteins, and mutations lead to pathologies with vastly different clinical presentations? And why do individuals with neurodevelopmental disorders, such as autism and schizophrenia, face higher chances of cancer emerging throughout their lifetime? Our broad review emphasizes the multi-scale aspect of this type of reasoning. As these examples demonstrate, rather than focusing on a… Show more
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