Review : Biodegradability of Synthetic Polymers for Medical and Pharmaceutical Applications: Part 3—Pendent Group Hydrolysis and General Conclusions

Pierre, Thomas St.; Chiellini, Emo

doi:10.1177/088391158700200305

Cited by 9 publications

(1 citation statement)

References 35 publications

(51 reference statements)

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“…Research has been active in the search for alternatives; three areas have been earmarked. The first emphasizing synthetic polymers with groups susceptible to biodegradation (Pierre, et al, ,1987), the second approach is the use of biopolymers such as PHA (polyhydroxy alkanoates), PHB(polyhydroxy butyrate), PLA(polylactic acid), PHV(polyhydroxy valerate) (Holmens, et al,1984). The third method is blending of some of the culprit plastics with biodegradable fillers (Shogren, 1989;Bastioli, 1995).…”

Section: Introductionmentioning

confidence: 99%

Degradation and Moisture Absorption Study of Potato-starch Linear Low Density Polyethylene Blend

Yakubu¹,

Musa²,

Mukaila³

2010

Nig J Bas App Sci

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Composite of linear low density polyethylene (LLDPE) and potato-starch was produced and subjected to degradation studies with the agencies of enzymes, exposure to weather and immersion in water. Enzymatic hydrolysis degraded the matrix to an extent greater than 40% loss in strength and about 20% loss in elongation-at-break within just 10 days. These deteriorations correlated with the decrease in weight. Immersion in water indicated increased uptakes with starch content which also corresponded with decrease in tensile strength and elongation-at-break with time of immersion. Exposure to weather completely reduced the composites to easily crushable masses the extent of which was also related to starch content. Micrographs of the tested samples showed that the weak points are the starch sections which after being eaten up by microorganisms or swollen up by moisture lend the matrix more amenable to further degradation.

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Section: Introductionmentioning

confidence: 99%

Degradation and Moisture Absorption Study of Potato-starch Linear Low Density Polyethylene Blend

Yakubu¹,

Musa²,

Mukaila³

2010

Nig J Bas App Sci

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Synthesis and properties of biodegradable copolyesteramides: Nylon 6,6/ϵ‐caprolactone copolymers, 1

Arvanitoyannis

Nakayama

Kawasaki

et al. 1994

Angew. Makromol. Chem.

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A series of copolyesteramides based on adipic acid/l,6-hexane diamine/&-caprolactone and Nylon 6,6 salt/&-caprolactone were synthesized. Their molecular weights, determined by gel permeation chromatography and NMR spectroscopy, were found to lie within the range from 1 000 up to 7000. Their thermal properties (glass transitions, melting points and heats of melting, and decomposition temperatures) were recorded with differential scanning calorimetry and thermogravimetry, respectively, and correlated to the comonomer feed composition. The FT-IR and NMR spectra were also recorded in order to confirm the composition of the copolyesteramides and to compare them with that of the comonomer feed. The biodegradability of the synthesized copolymers was tested by enzymatic hydrolysis. ZUSAMMENFASSUNG:Eine Reihe von Copolyesteramiden mit Molekulargewichten zwischen 1 OOO und 7 000 (GPC, NMR) wurden aus Adipinsaure/l,6-Hexandiamin/~-Caprolacton bzw.Nylon 6,6-Salz/&-CaproIacton hergestellt . Die thermischen Eigenschaften der synthetisierten Polymeren (Glasiibergangs-, Schmelz-, und Zersetzungstemperaturen, Schmelzenthalpien) wurden durch DSC-und TGA-Messungen bestimmt und in Bezug auf das Comonomerverhaltnis in der Ausgangsmischung diskutiert. Die Ubereinstimmung der Copolymerzusammensetzung mit dem Ausgangscomonomerverhaltnis wurde mit FT-IR-und NMR-Spektroskopie untersucht. Die Bioabbaubarkeit der Copolyesteramide wurde durch enzymatische Hydrolyse gepriift.

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Evaluation of polyphosphates and polyphosphonates as degradable biomaterials

Richards

Dahiyat

et al. 1991

J. Biomed. Mater. Res.

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A series of polymers, bisphenol A-based poly(phosphoesters), were evaluated as degradable biomaterials. Degradation was observed for the four polymers studied under both in vitro and in vivo conditions. The rate of degradation was affected by polymer side-chain structure and correlated with the swelling behavior. The ethyl side-chain polymers absorbed more water than their phenyl counterparts. Among the sterilization methods, UV irradiation followed by antibiotic treatment was the most suitable, as steam autoclave and ethylene oxide treatments altered the properties of several of the poly (phosphoesters). Tissue response to the poly(phosphoesters) in rabbits was characterized by minor encapsulation and slight or no lymphocyte, giant cell, or macrophage activity. No evidence of edema or necrosis was found. The elastic moduli of these materials varied from 488 MPa for poly(bisphenol A-ethylphosphate) (BPA/EOP) to 627 MPa for the more rigid poly(bisphenol A-phenylphosphonate) (BPA/PP). The ultimate strength, modulus, and energy to failure of BPA/PP were lower than those of similarly compression molded high-molecular-weight poly(L-lactic acid) (PLLA).

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Review : Biodegradability of Synthetic Polymers for Medical and Pharmaceutical Applications: Part 3—Pendent Group Hydrolysis and General Conclusions

Cited by 9 publications

References 35 publications

Degradation and Moisture Absorption Study of Potato-starch Linear Low Density Polyethylene Blend

Degradation and Moisture Absorption Study of Potato-starch Linear Low Density Polyethylene Blend

Synthesis and properties of biodegradable copolyesteramides: Nylon 6,6/ϵ‐caprolactone copolymers, 1

Evaluation of polyphosphates and polyphosphonates as degradable biomaterials

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