ReviewCutaneous manifestations due toPseudomonasinfection

Modification of In Vivo and In Vitro T- and B-Cell-Mediated Immune Responses by thePseudomonas aeruginosaQuorum-Sensing MoleculeN-(3-Oxododecanoyl)-l-Homoserine Lactone

“…P. aeruginosa is a significant pathogen of immunocompromised individuals, including burn patients (24,38,39,49), and human immunodeficiency virus and AIDS patients (1,17), and patients with the genetic disorder cystic fibrosis (15,22), and is a common cause of ocular (21) and cutaneous (45) infections. OdDHL is clearly an important factor in the pathogenesis of P. aeruginosa because of its role in the control of the expression of virulence factors, such as elastase, alkaline protease, and pyoverdine (12,16,34,36,37,52), and it has been demonstrated in animal models that strains of P. aeruginosa which produce no OdDHL or which are resistant to its actions are less virulent than OdDHL-producing strains (35,53).…”

Pseudomonas aeruginosa in the Early Childhood: A Case Report

“…Actually, while the child was in hospital, gentamicin and ciprofl oxacin were used in order to combat the infection. The antibiotics that are most mostly used in PA infection's treatment are penicilins such as Piperacillin and Ticarcillin, aminoglycosides like Gentamicin and Amikacin, Imipenem, Quinolones, Aztreonam and Cephalosporines are also used [1,2,7,8,14,15]. Currently there is not a vaccine to protect against PA.…”

“…It can also cause necrotizing pneumonia through contaminated respiratory equipment, necrotizing external otitis in elderly diabetic patients; ocular infection after surgical procedures or wounds; urinary tract infections through the insertion of catheters or irrigation solutions; meningitis after neurosurgery or endorcaditis after surgery or catheter usage [1]. Furthermore, infected wounds and burns produces a greenish-blue exudate which is fl uorescent under ultraviolet light and may present a characteristic odor of grapefruit [1,2,7,8].…”

“…In this case, it is classical the presence of skin hemorrhagic necrosis characterized by round erythematosus lesions, denominated ecthyma gangrenosum, which can be occurred in 15% of Pseudomonas aeruginosa septcemia. Clinically, it starts as an infl ammatory plaque, papule, or macule, reddish in color, edematous, and painful, which in less than 12-24 h develops into a hemorrhagic blister, vesicle pustule, or nodule with a narrow infl ammatory rim [2,[8][9][10].…”

Pseudomonas aeruginosa flagellum is critical for invasion, cutaneous persistence and induction of inflammatory response of skin epidermis

“…This ubiquitous Gram-negative bacterium belongs to the transient skin microflora when the epithelial barrier function is compromised ( e.g . wound, burn, ulcer…] or in moist regions of the skin of just 2% of non-hospitalized healthy persons [7]. P. aeruginosa is involved in acute cutaneous infections in which the skin is a primary focus, usually occurring in patients with a local contributive factor [8] or in which cutaneous lesions are a consequence of a bacteremia, mostly in immunocompromised patients [9].…”