Review article: chronic constipation and food hypersensitivity – an intriguing relationship

Carroccio, Antonio; Iacono, Giuseppe

doi:10.1111/j.1365-2036.2006.03125.x

Cited by 36 publications

(30 citation statements)

References 43 publications

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“…Furthermore, patients were assigned randomly, and with a double-blind method, to one of the two dietary treatment groups: Group A was treated with a " sham diet " based on the elimination of rice, potato, lamb, bean, and peas; Group B received a " true-elimination diet " based on the elimination of cow ' s milk and its derivatives, wheat, egg, tomato, and chocolate. Th ese elimination diets were arbitrarily chosen on the basis of our previous experience ( 14,18,19 ), as the foods eliminated in Group A were almost always tolerated, whereas the foods eliminated in Group B were those that most frequently caused symptoms in subjects with chronic constipation due to FH. Th e patients kept a dietary diary, and adherence to the elimination diet was evaluated by trained dieticians.…”

Section: Methodsmentioning

confidence: 99%

Oligo-Antigenic Diet in the Treatment of Chronic Anal Fissures. Evidence for a Relationship Between Food Hypersensitivity and Anal Fissures

Carroccio

Mansueto

Morfino

et al. 2013

American Journal of Gastroenterology

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OBJECTIVES:Patients with chronic constipation due to food hypersensitivity (FH) had an elevated anal sphincter resting pressure. No studies have investigated a possible role of FH in anal fi ssures (AFs). We aimed to evaluate (1) the effectiveness of diet in curing AFs and to evaluate (2) the clinical effects of a double-blind placebo-controlled (DBPC) challenge, using cow ' s milk protein or wheat. METHODS:One hundred and sixty-one patients with AFs were randomized to receive a " true-elimination diet " or a " sham-elimination diet " for 8 weeks; both groups also received topical nifedipine and lidocaine. Sixty patients who were cured with the " true-elimination diet " underwent DBPC challenge in which cow ' s milk and wheat were used. RESULTS:At the end of the study, 69 % of the " true-diet group " and 45 % of the " sham-diet group " showed complete healing of AFs ( P < 0.0002). Thirteen of the 60 patients had AF recurrence during the 2-week cow ' s milk DBPC challenge and 7 patients had AF recurrence on wheat challenge. At the end of the challenge, anal sphincter resting pressure signifi cantly increased in the patients who showed AF reappearance ( P < 0.0001), compared with the baseline values. The patients who reacted to the challenges had a signifi cantly higher number of eosinophils in the lamina propria and intraepithelial lymphocytes than those who did not react to the challenges.CONCLUSIONS: An oligo-antigenic diet combined with medical treatment improved the rate of chronic AF healing. In more than 20 % of the patients receiving medical and dietary treatment, AFs recurred on DBPC food challenge .

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Section: Methodsmentioning

confidence: 99%

Oligo-Antigenic Diet in the Treatment of Chronic Anal Fissures. Evidence for a Relationship Between Food Hypersensitivity and Anal Fissures

Carroccio

Mansueto

Morfino

et al. 2013

American Journal of Gastroenterology

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“…Constipation, in most cases, is short-term and has few consequences, but sometimes lasts more than six months and is not treated by routine treatments. Other causes of chronic constipation in children include insufficient diet, the use of some medications, metabolic and endocrine causes, uremia, hypothyroidism, central nervous system tissue disorders, diabetes, and connective tissue diseases [8][9][10][11][12]. To treat constipation, therapeutic measures such as nutritional methods, feedback training, osmotic laxatives and stimulants, as well as stool volumizers, are used.…”

Section: Introductionmentioning

confidence: 99%

Concise review: Herbal remedies and herbal plants for constipation in children

2018

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Background: Constipation refers to difficult or delayed bowel emptying lasting 2 weeks or more and causing anxiety and distress in patients, and it is one of the most common problems in children. To treat constipation, therapeutic measures such as nutritional methods, feedback training, osmotic laxatives and stimulants, as well as stool volume enhancers, are used; however, each has its own problems and side effects. Medicinal plants have been shown to be effective in the treatment of many diseases, including constipation. Therefore, this review was conducted to report the medicinal plants effective for constipation. Methods: In the current review, eligible articles indexed from databases such as ISI (Web of Science), PubMed, Scopus, Islamic World Science Citation Center, Scientific Information Database, and Magiran were retrieved using the keywords ‘constipation’, ‘children constipation’, ‘baby’s and newborn constipation’, ‘medicinal plants’, and ‘traditional medicine’. Results: Available evidence showed that the medicinal plants Olea europaea, Phaseolus vulgaris, Prunus armeniaca, Brassica oleracea var. italica, Malus domestica, Linum usitatissimum, Aloe vera, Vitis vinifera, Foeniculum vulgare, Ficus carica, Ricinus communis, Sesamum indicum, and Descurainia sophia are some of the most important medicinal plants for the treatment of constipation in traditional medicine. Conclusion: Herbal plants are important for isolation/ preparation of new drugs in the treatment of constipation in children. In future studies, it may be beneficial to further understand and classify herbal plants/remedies, based on their mechanisms, as laxatives in the treatment of constipation.

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“…Colonic seromuscular biopsies (collected laparoscopically) may be more useful for children with dysmotility proximal to the anorectum. However, rectal mucosal biopsy can be useful for the diagnosis of food intolerance/allergy if eosinophilia and mast cells are demonstrated (Carroccio et al 2000;Daher et al 2001;Carroccio & Iacono 2006;Scaillon & Cadranel 2006). Some centres advocate the identification of "the site of slowing in the colon" to decide on the part/segment of the colon to be resected in patients with intractable symptoms, desperate for a cure (Youssef et al 2004).…”

Section: Clinical Importancementioning

confidence: 99%

Targeting the Causes of Intractable Chronic Constipation in Children: The Nuclear Transit Study (NTS)

Yik¹,

Cook²,

Veysey³

et al. 2011

Radioisotopes - Applications in Bio-Medical Science

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Review article: chronic constipation and food hypersensitivity – an intriguing relationship

Abstract: SUMMARY BackgroundChronic constipation is common in the general population. Some studies have shown that in children cow's milk protein hypersensitivity can cause chronic constipation unresponsive to laxative treatment.

Cited by 36 publications

References 43 publications

Oligo-Antigenic Diet in the Treatment of Chronic Anal Fissures. Evidence for a Relationship Between Food Hypersensitivity and Anal Fissures

Oligo-Antigenic Diet in the Treatment of Chronic Anal Fissures. Evidence for a Relationship Between Food Hypersensitivity and Anal Fissures

Concise review: Herbal remedies and herbal plants for constipation in children

Targeting the Causes of Intractable Chronic Constipation in Children: The Nuclear Transit Study (NTS)

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