Review Article

Madej, T.H.; Paasuke, R. T.

doi:10.1007/bf03015163

Cited by 33 publications

(1 citation statement)

References 190 publications

(10 reference statements)

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“…[ 9 ] However, oral premedicants are frequently rejected by children even when palatable. [ 10 ] Only 16% of ketamine is bio available by oral route and bioavailability of oral midazolam is 27%. [ 11 12 ]…”

Section: Discussionmentioning

confidence: 99%

A comparison of intranasal ketamine and intranasal midazolam for pediatric premedication

Naphade

Nallamilli

et al. 2015

Anesth Essays Res

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Aims and Objectives:The aim of our study is to compare the efficacy and side-effects of Ketamine and Midazolam administered nasally for the pediatric premedication.Materials and Methods:We studied 100 American Society of Anesthesiology I and II children aged from 1 to 10 years undergoing various surgical procedures. Totally, 50 children were evaluated for nasal ketamine (using 50 mg/ml vials) at the dose of 5 mg/kg and the other 50 received nasal midazolam 0.2 mg/kg, before induction in operation theater each patient was observed for onset of sedation, degree of sedation, emotional status being recorded with a five point sedation scale, response to venipuncture and acceptance of mask, whether readily, with persuasion or refuse.Results:The two groups were homogenous. Midazolam showed a statistically significant early onset of sedation (10.76 ± 2.0352 vs. 16.42 ± 2.0696 min). There were no significant differences in venipuncture score, sedation scale at 20 min, acceptance of mask and oxygen saturation throughout the study. Significant tachycardia and ‘secretions were observed in the ketamine group intra operatively. Postoperatively emergence (8% vs. 0%) and secretions (28% vs. 4%) were significant in the ketamine group. Nausea and vomiting occurred in l6% versus 10% for midazolam and ketamine group.Conclusions:Both midazolam and ketamine nasally are an effective pediatric premedication. Midazolam has an early onset of sedation and is associated with fewer side-effects.

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Section: Discussionmentioning

confidence: 99%

A comparison of intranasal ketamine and intranasal midazolam for pediatric premedication

Naphade

Nallamilli

et al. 2015

Anesth Essays Res

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Premedication for Surgery A Survey of Australian Practice

Riley

Lim

1999

The Australian Journal of Hospital Pharmacy

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Objective: To survey anaesthetists' premedication practices for adult surgical patients. Methods: With institutional approval, a survey questionnaire was given to anaesthetists in Western Australia during January-May 1995. The survey was anonymous and contained 16 questions. Seven responses were recorded using an anchored, 100 mm visual analogue scale (VAS). Two clinical scenarios were described and respondents were asked to detail their use of premedication drugs. Participants: Consultant and trainee anaesthetists practising in Western Australia. Results: Completed forms were returned by 107 anaesthetists. Respondents were aged 27-63 yr (mean age 42 ± 9 yr) and were grouped by staff position (77% consultant, 23% trainee), sex (85% male) and years of practice. In general, inpatients were visited on the day before surgery (VAS = 86) but not always questioned about their anxiety (VAS = 56). Anaesthetists believed that premedication itself was somewhat important (VAS= 67) and that patients expect premedication drugs to be used more often than not (VAS = 68).

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Kontrollierte Analgosedierung zur Erleichterung ausgedehnter Eingriffe in Lokalanästhesie

Diem¹

1989

Operationsplanung Und Erfolgskontrolle

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Review Article

Cited by 33 publications

References 190 publications

A comparison of intranasal ketamine and intranasal midazolam for pediatric premedication

A comparison of intranasal ketamine and intranasal midazolam for pediatric premedication

Premedication for Surgery A Survey of Australian Practice

Kontrollierte Analgosedierung zur Erleichterung ausgedehnter Eingriffe in Lokalanästhesie

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