Review: Application of chitosan and its derivatives in medical materials

Wen, Tian; Wang, Juan; Hou, Huiwen; Li, Yan; Wang, Jie; Fu, Jiaai; Lu, Lu; Gao, Didi; Zengmei, Liu; Zhao, Fei; Gao, Xueshan; Ling, Peixue; Wang, Fengshan; Feng, Shengyu; Tan, Haining

doi:10.1016/j.ijbiomac.2023.124398

Cited by 57 publications

(23 citation statements)

References 176 publications

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“…Chitosan, a commonly used biomedical material, is known for its non-toxicity, good biocompatibility, and degradability [ 35 ]. A variety of studies confirmed that chitosan could be an ideal biomaterial as antiseptic dressing, drug carrier and embolization for medical applications [ 36 , 37 ]. PDA is a reliable surface coating material, or can be synthesized as nano-platform for loading 131 I, as it exhibits excellent both in vivo and in vitro stability [ 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Polymer composite microspheres loading ¹⁷⁷ Lu radionuclide for interventional radioembolization therapy and real-time SPECT imaging of hepatic cancer

Xiao,

Li,

Geng

et al. 2023

Biomater Res

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Background Transarterial radioembolization (TARE) with 90Y-labeled glass and resin microspheres is one of the primary treatment strategies for advanced-stage primary and metastatic hepatocellular carcinoma (HCC). However, difficulties of real-time monitoring post administration and embolic hypoxia influence treatment prognosis. In this study, we developed a new biodegradable polymer microsphere that can simultaneously load 177Lu and MgO nanoparticle, and evaluated the TARE therapeutic efficacy and biosafety of 177Lu-PDA-CS-MgO microspheres for HCC treatment. Methods Chitosan microspheres were synthesized through emulsification crosslink reaction and then conducted surface modification with polydopamine (PDA). The 177Lu and nano MgO were conjugated to microspheres using active chemical groups of PDA. The characteristics of radionuclide loading efficiency, biodegradability, blood compatibility, and anti-tumor effectwere evaluated both in vitro and in vivo. SPECT/CT imaging was performed to monitor bio-distribution and bio-stability of 177Lu-PDA-CS-MgO after TARE treatment. The survival duration of each rat was monitored. HE analysis, TUNEL analysis, immunohistochemical analysis, and western blot analysis were conducted to explore the anti-tumor effect and mechanism of composited microspheres. Body weight, liver function, blood routine examination were monitored at different time points to evaluate the bio-safety of microspheres. Results The composite 177Lu-PDA-CS-MgO microsphere indicated satisfactory degradability, biocompatibility, radionuclide loading efficiency and radiochemical stability in vitro. Cellular evaluation showed that 177Lu-PDA-CS-MgO had significant anti-tumor effect and blocked tumor cell cycles in S phase. Surgical TARE treatment with 177Lu-PDA-CS-MgO significantly prolonged the medial survival time from 49 d to 105 d, and effectively inhibited primary tumor growth and small metastases spreading. Moreover, these microspheres indicated ideal in vivo stability and allowed real-time SPECT/CT monitoring for up to 8 weeks. Immunostaining and immunoblotting results also confirmed that 177Lu-PDA-CS-MgO had potential in suppressing tumor invasion and angiogenesis, and improved embolic hypoxia in HCC tissues. Further evaluations of body weight, blood test, and pathological analysis indicated good biosafety of 177Lu-PDA-CS-MgO microspheres in vivo. Conclusion Our study demonstrated that 177Lu-PDA-CS-MgO microsphere hold great potential as interventional brachytherapy candidate for HCC therapy. Graphical Abstract Polymer composite microspheres loading 177Lu radionuclide and MgO nanoparticles for interventional radioembolization therapy and real-time SPECT imaging of hepatic cancer.

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Section: Discussionmentioning

confidence: 99%

Polymer composite microspheres loading ¹⁷⁷ Lu radionuclide for interventional radioembolization therapy and real-time SPECT imaging of hepatic cancer

Xiao,

Li,

Geng

et al. 2023

Biomater Res

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“…As a result, it damages the bacterial cell wall, disrupting metabolism and leading to the death of the bacteria. Therefore, chitosan’s antibacterial activity is high under acidic conditions [ 136 ].…”

Section: Antibacterial Activity Of Chitosan and Its Derivativesmentioning

confidence: 99%

Chitosan and Its Derivatives: Preparation and Antibacterial Properties

Egorov,

Kirichuk,

Rubanik

et al. 2023

Materials

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This comprehensive review illuminates the various methods of chitosan extraction, its antibacterial properties, and its multifarious applications in diverse sectors. We delve into chemical, physical, biological, hybrid, and green extraction techniques, each of which presents unique advantages and disadvantages. The choice of method is dictated by multiple variables, including the desired properties of chitosan, resource availability, cost, and environmental footprint. We explore the intricate relationship between chitosan’s antibacterial activity and its properties, such as cationic density, molecular weight, water solubility, and pH. Furthermore, we spotlight the burgeoning applications of chitosan-based materials like films, nanoparticles, nonwoven materials, and hydrogels across the food, biomedical, and agricultural sectors. The review concludes by highlighting the promising future of chitosan, underpinned by technological advancements and growing sustainability consciousness. However, the critical challenges of optimizing chitosan’s production for sustainability and efficiency remain to be tackled.

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“…The structural properties of CH vary according to the degree of deacetylation, molecular weight, and product grade. Due to these variations, the applications of CH have become broader and extended to many different fields such as it is reported as an excellent base material for food packaging, cosmetics, wound dressing, tissue engineering, drug delivery, and adsorbent in wastewater remediation [ 8 , 12 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Aloe vera/Chitosan-Based Edible Film with Enhanced Antioxidant, Antimicrobial, Thermal, and Barrier Properties for Sustainable Food Preservation

Kaur,

Somasundram,

Razali

et al. 2024

Polymers

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Food bioactive packaging has received increasing attention from consumers and the food industry for its potential to reduce food waste and environmental issues. Several materials can be used to produce edible films/coats; however, bio-based, cost-effective, and sustainable coatings have gained a high reputation these days. For instance, Aloe vera gel (AV) is a promising bio-based material for edible coatings and films; therefore, the present study aimed to investigate the film-forming abilities of AV and Chitosan (CH) combination as a potential active food packaging material. The physicochemical and mechanical characteristics of formed films of various combinations were prepared at different concentrations, i.e., CH (0.5% w/v), AV (100%), CH:AV (75:25), and CH:AV (60:40). The results showed significant differences among all the prepared edible films wherein these differences were mainly on account of incorporating AV gel. The rheological and antioxidant properties of the formulations improved with the inclusion of AV gel. The films composed of CH:AV (60:40) positively affected the water solubility, thermal properties, and water vapour permeability of the edible films. The X-ray Diffraction (XRD) and Scanning electron microscopy (SEM) results showed that the films composed of CH:AV, (60:40) were amorphous and had smooth morphology. Further, the edible film solutions were applied to fresh figs (Ficus carica) to investigate their role in preserving fruits during storage. A significant reduction in microbial growth was found in coated fruits after 28 days of cold storage. The films composed of CH and AV showed overall improved results compared to the CH (0.5%, w/v). Therefore, the used formulations (CH:AV, 60:40) can form a sustainable film that has the potential to be utilized for fresh product preservation to maintain its quality and shelf life.

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Review: Application of chitosan and its derivatives in medical materials

Cited by 57 publications

References 176 publications

Polymer composite microspheres loading ¹⁷⁷ Lu radionuclide for interventional radioembolization therapy and real-time SPECT imaging of hepatic cancer

Polymer composite microspheres loading ¹⁷⁷ Lu radionuclide for interventional radioembolization therapy and real-time SPECT imaging of hepatic cancer

Chitosan and Its Derivatives: Preparation and Antibacterial Properties

Aloe vera/Chitosan-Based Edible Film with Enhanced Antioxidant, Antimicrobial, Thermal, and Barrier Properties for Sustainable Food Preservation

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Review: Application of chitosan and its derivatives in medical materials

Cited by 57 publications

References 176 publications

Polymer composite microspheres loading 177 Lu radionuclide for interventional radioembolization therapy and real-time SPECT imaging of hepatic cancer

Polymer composite microspheres loading 177 Lu radionuclide for interventional radioembolization therapy and real-time SPECT imaging of hepatic cancer

Chitosan and Its Derivatives: Preparation and Antibacterial Properties

Aloe vera/Chitosan-Based Edible Film with Enhanced Antioxidant, Antimicrobial, Thermal, and Barrier Properties for Sustainable Food Preservation

Contact Info

Product

Resources

About

Polymer composite microspheres loading ¹⁷⁷ Lu radionuclide for interventional radioembolization therapy and real-time SPECT imaging of hepatic cancer

Polymer composite microspheres loading ¹⁷⁷ Lu radionuclide for interventional radioembolization therapy and real-time SPECT imaging of hepatic cancer