Review : Anti-endothelial cell antibodies in systemic autoimmune diseases: prevalence and clinical significance

Navarro, M.A.; Cervera, Ricard; Font, Josep; Jc, Reverter; Monteagudo, Joan; Escolar, Ginés; López‐Soto, Alfons; Ordinas, A; Ingelmo, M

doi:10.1177/096120339700600608

Cited by 79 publications

(42 citation statements)

References 25 publications

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“…18,19 Antibody-mediated endothelial damage also has been described in many diseases, including primary autoimmune vasculitides, 20,21 systemic autoimmune diseases with vascular involvement, 22,23 as well as the early and late stages of atherosclerosis. Among primary autoimmune vasculitides such as Wegener granulamatosis, Kawasaki disease, and Henoch-Schonlein purpura, there is an association between antiendothelial cell antibodies (AECA) and disease status.…”

Section: Introductionmentioning

confidence: 99%

“…Among primary autoimmune vasculitides such as Wegener granulamatosis, Kawasaki disease, and Henoch-Schonlein purpura, there is an association between antiendothelial cell antibodies (AECA) and disease status. [22][23][24][25][26][27] Systemic lupus erythematosus also shows a relationship between AECA prevalence and disease status. 28,29 Indeed, transfer of AECA into rabbits results in systemic lupus erythematosus-like nephritis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium

Pham¹,

Gregg²,

Karp³

et al. 2009

Blood

111

138

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Humans are genetically unable to synthesize the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc). However, Neu5Gc can be metabolically incorporated and covalently expressed on cultured human cell surfaces. Meanwhile, humans express varying and sometimes high titers of polyclonal anti-Neu5Gc antibodies. Here, a survey of human tissues by immunohistochemistry with both a monospecific chicken anti-Neu5Gc antibody and with affinity-purified human antiNeu5Gc antibodies demonstrates endothelial expression of Neu5Gc, likely originating from Neu5Gc-rich foods like red meats. We hypothesized that the combination of Neu5Gc incorporation and anti-Neu5Gc antibodies can induce endothelial activation. Indeed, the incubation of high-titer human sera with Neu5Gc-fed endothelial cells led to Neu5Gc-dependent antibody binding, complement deposition, endothelial activation, selectin expression, increased cytokine secretion, and monocyte binding. The proinflammatory cytokine tumor necrosis factor-␣ also selectively enhanced human anti-Neu5Gc antibody reactivity. AntiNeu5Gc antibodies affinity-purified from human serum also directed Neu5Gc-dependent complement deposition onto cultured endothelial cells. These data indicate a novel human-specific mechanism in which Neu5Gc-rich foods deliver immunogenic Neu5Gc to the endothelium, giving anti-Neu5Gc antibody-and complement-dependent activation, and potentially contributing to human vascular pathologies. In the case of atherosclerosis, Neu5Gc is present both in endothelium overlying plaques and in subendothelial regions, providing multiple pathways for accelerating inflammation in this disease.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium

Pham¹,

Gregg²,

Karp³

et al. 2009

Blood

111

138

View full text Add to dashboard Cite

show abstract

“…These are attractive candidate biomarkers for autoimmune diseases including SLE, BD, RA, and Takayasu's vasculitis and their prevalence ranges from 15 to 88%. 17,[29][30][31][32][33] Some additional data suggest that AECAs have an immunogenic role by triggering endothelial cell activation and vascular damage. 18,31 However, neither the antigenic targets nor their role in physiopathology have yet been established.…”

Section: Ve-cadherin Antibodies In Autoimmune Disease L Bouillet Et Almentioning

confidence: 99%

Auto-antibodies to vascular endothelial cadherin in humans: association with autoimmune diseases

Bouillet

Baudet

Deroux

et al. 2013

Laboratory Investigation

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“…Miano przeciwciał AECA w klasie IgM korelowało ponadto z aktywnością choroby [50]. Jednak większość badań na małych grupach chorych wskazuje na zmienność wystę-powania przeciwciał AECA w TA [51][52][53][54]. Eichhorn i wsp.…”

Section: Badania Laboratoryjneunclassified

Takayasu arteritis: is disease activity assessment possible?

Rowińska-Osuch¹,

Więsik-Szewczyk²,

Olesińska³

2013

Reumatologia

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P Pr ra ac ca a w wp pł ły yn nę ęł ła a: : 22.05.2012 r. S t r e s z c z e n i eChoroba Takayasu (TA) jest rzadkim zapaleniem dużych tętnic. Początek choroby jest podstępny, może pozostać niezauważony. Przewlekłe zapalenie prowadzi do nieodwracalnych konsekwencji: powikłań sercowo-naczyniowych, niedrożności naczyń, zaniewidzenia czy przełomu nadciśnieniowego. Z uwagi na układowy charakter schorzenia pacjenci trafiają do specjalistów różnych dziedzin: reumatologów, okulistów, kardiologów i chirurgów naczyniowych. Dostępne metody farmakoterapii wpływają tylko na aktywne zmiany zapalne. Przedłużające się leczenie glikokortykosteroidami ma niekorzystne skutki odległe i nie powinno być nadużywane. Aby określić efekt leczenia, wybrać moment jego modyfikacji, konieczna jest ocena aktywności choroby. Celem prezentowanej pracy jest przedstawienie możliwości oceny aktywności TA. W diagnostyce znaczącą rolę odgrywają badania obrazowe naczyń: ultrasonografia i rezonans magnetyczny. Prowadzone są prace dotyczące pozytonowej tomografii emisyjnej (positron emission tomography -PET), która jest badaniem czułym, ale trudno dostępnym, kosztownym i wymagającym walidacji. Poszukuje się również biomarkera, którego wartości korelowałyby z aktywnością choroby. Wśród potencjalnych kandydatów na biomarker są interleukiny 6, 12, 18. Aktualnie opracowywane są skale aktywności choroby, np. DEI.Tak (Disease Extent Index-Takayasu). Żadne z tych narzędzi nie jest uniwersalne.

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Review : Anti-endothelial cell antibodies in systemic autoimmune diseases: prevalence and clinical significance

Abstract: Patients with systemic autoimmune diseases have a high prevalence of AECA and they are associated with the presence of vascular lesions, nephropathy, and aCL in SLE, as well as with disease activity in several primary systemic vasculitis (TA, PAN, WG and BD).

Cited by 79 publications

References 25 publications

Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium

Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium

Auto-antibodies to vascular endothelial cadherin in humans: association with autoimmune diseases

Takayasu arteritis: is disease activity assessment possible?

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