Review and Updates in Regenerative and Personalized Medicine, Preclinical Animal Models, and Clinical Care in Cardiovascular Medicine

Abstract

The goal of this paper is to provide an updated review for scientists and clinicians on the major areas in cardiovascular medicine published in the Journal. Leading topics in regenerative and personalized medicine are presented along with a critical overview of the field. New standards in large preclinical animal models of pulmonary hypertension and left bundle branch block are highlighted. Finally, clinical care in the areas of atherosclerosis, the aortic valve, platelet biology, and myocarditis is discussed as well as autonomic modulation therapies

Calcific Aortic Valve Disease: Part 2—Morphomechanical Abnormalities, Gene Reexpression, and Gender Effects on Ventricular Hypertrophy and Its Reversibility

“…1). Nevertheless, emerging evidence supports a dynamic view of the myocardium in which cardiomyocyte death and renewal, mediated by exogenous and endogenous stem/progenitor cells, are vital components of cardiac remodeling processes that lead to homeostatic dynamic outcomes [7–9]. Thus, it now appears likely that, since there are cardiac progenitor cells that may systematically replace damaged cardiomyocytes, then it will probably be possible over the next few years to augment cardiac regeneration via their stimulation, culture, expansion, and/or transplantation.…”

“…Considering that our understanding of the (patho) physiological relevance of lncRNAs is currently confined within the context of heart regeneration, it is envisioned that they will initially form an essential component of the emerging field of myocardial regenerative medicine [7–9, 156–160]. It is not yet established whether lncRNAs are significantly involved in the regulation of cardiac hypertrophy, but one lncRNA (cardiac hypertrophy related factor, CHRF) serves as an endogenous sponge of miR-489 and allows the expression of the myeloid differentiation primary response gene 88 ( Myd88 ), which activates hypertrophic adaptive response processes [161].…”

Patient-Specific Numerical Simulations of Endovascular Procedures in Complex Aortic Pathologies: Review and Clinical Perspectives

“…Personalized medicine involves managing health based on individual characteristics and has great potential to improve the care of patients suffering from cardiovascular diseases [1,2]. In recent years, research in this field has focused significantly on gene-targeted drug therapy.…”