Review and Recommendations for Drug Testing in Substance Use Treatment Contexts

Jaffe, Adi; Molnar, Sean; Williams, Nicole; Wong, Emily H. M.; Todd, Therese; Caputo, C.; Tolentino, Jessica; Ye, Shirlee

doi:10.17756/jrdsas.2016-025

Cited by 9 publications

(2 citation statements)

References 106 publications

(180 reference statements)

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“…20 The advantages and disadvantages of each specimen type are summarized in other review articles. 4,20,21 Urine remains the predominant specimen for clinical opioid testing, although it is susceptible to adulteration or substitution. 4 There are 2 major types of drug tests: screening and confirmatory.…”

Section: Opioid Point-of-care Testingmentioning

confidence: 99%

Point-of-Care Drug of Abuse Testing in the Opioid Epidemic

Wang

2020

Archives of Pathology &Amp; Laboratory Medicine

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Context.— The United States is experiencing an opioid overdose epidemic. Point-of-care (POC) drug of abuse testing is a useful tool to combat the intensified opioid epidemic. Objectives.— To review commercially available POC drug of abuse testing involving opioids, to review opportunities and challenges for POC opioid testing and emerging testing methods in research literature, and finally to summarize unmet clinical needs and future development prospects. Data Sources.— The Google search engine was used to access information for commercial opioid POC devices and the Google Scholar search engine was used to access research literature published from 2000 to 2019 for opioid POC tests. Conclusions.— The opioid epidemic provides unprecedented opportunities for POC drug testing, with significant clinical needs. Compared with gold standard tests, limitations for commercially available opioid POC testing include lower analytical sensitivity, lower specificity, and cross-reactivity. In response to unmet clinical needs, novel methods have emerged in research literature, such as microfluidics and miniature mass spectrometry. Future prospects include the development of quantitative POC devices and smarter and real-time drug testing.

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Section: Opioid Point-of-care Testingmentioning

confidence: 99%

Point-of-Care Drug of Abuse Testing in the Opioid Epidemic

Wang

2020

Archives of Pathology &Amp; Laboratory Medicine

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“…In recent years, studies done on hair analysis have shown promising results. There is longer window period of detection in hair as compared to urine, which is about 30 days in chronic drug abusers [8]. Hair cannabinoid analysis mainly includes the psychoactive Δ9tetrahydrocannabinol (THC) and its metabolite 11-nor-9-carboxy-Δ 9tetrahydrocannabinol (THC-COOH).…”

Section: P R O V I S I O N a L L Ymentioning

confidence: 99%

Diagnostic accuracy of cannabinoid testing by liquid chromatography-tandem mass spectrometry in human hair

et al. 2020

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Abstract Objective: To determine the diagnostic accuracy of Cannabinoids testing by LC-MS/MS in human hair and compare it with urine in civil heavy vehicle drivers. Materials and Methods: Current study was a diagnostic accuracy study done in “Armed Forces Institute of Pathology Rawalpindi, Pakistan” from February to November 2017. Urine and hair samples were collected by non-probability convenient sampling technique from 151 heavy vehicle drivers from Punjab. Hair and urine samples were collected from each subject. Separation of compounds was performed on Agilent Poroshell and analyzed using 6460 Triple Quadrapole LC-MS along-with software Mass hunter ©. Results: Study population (151 civil heavy vehicle drivers) was divided into three main divisions There were 69 (46%) truck drivers,43 (28.5%) twenty-wheeler drivers and 39 (26%) bus drivers. Mean age of study participants was 36±10.82 years. Paired t-test was applied to check mean difference between the two tests’ concentration (i.e urine and hair analysis for cannabis) which showed significant difference at p<0.001. Among the different factors of diagnostic accuracy in hair and urine specimens were: Sensitivity (96% and 62%), Specificity (93% and 95%) Positive Predictive Value (88% and 87%), Negative Predictive Value (97% and 82%) respectively. Overall diagnostic accuracy of Cannabinoids detection in hair was 94% while in urine it was 83%. ROC curve showed area under curve of 0.79 and 0.96 for urine and hair samples respectively. Continuous...

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Drug Testing in Addiction Medicine

Tremonti

Haber

2020

Textbook of Addiction Treatment

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Review and Recommendations for Drug Testing in Substance Use Treatment Contexts

Cited by 9 publications

References 106 publications

Point-of-Care Drug of Abuse Testing in the Opioid Epidemic

Point-of-Care Drug of Abuse Testing in the Opioid Epidemic

Diagnostic accuracy of cannabinoid testing by liquid chromatography-tandem mass spectrometry in human hair

Drug Testing in Addiction Medicine

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