Review and Prospects on the Ecotoxicity of Mixtures of Nanoparticles and Hybrid Nanomaterials

Zhang, Fan; Wang, Z.; Peijnenburg, Willie J.G.M.; Vijver, Martina G.

doi:10.1021/acs.est.2c03333

Cited by 50 publications

(23 citation statements)

References 90 publications

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“…To sum up, the joint effects of DCA and TDNMs on the freshwater algae are mainly additive, antagonistic, and synergistic, which are related to the type of species and the concentration of the mixed components. Previous studies also show joint toxic action with different types in the same mixture of ENPs and co-existing contaminants depending on test species [ 4 ] and the exposure levels of test materials [ 28 ].…”

Section: Resultsmentioning

confidence: 99%

“…The reality of pollution in the natural or artificial environment is that it is mostly a combined pollution. This also means that ENPs rarely exist alone but enter the environment at the same time as, or in sequence with, other pollutants and interact with each other to form combined pollution [ 4 ]. It is undeniable that the combined effect of ENPs with other pollutants on organisms is a worthwhile concern.…”

Section: Introductionmentioning

confidence: 99%

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An Insight into the Combined Toxicity of 3,4-Dichloroaniline with Two-Dimensional Nanomaterials: From Classical Mixture Theory to Structure-Activity Relationship

Wang

2023

IJMS

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The assessment and prediction of the toxicity of engineered nanomaterials (NMs) present in mixtures is a challenging research issue. Herein, the toxicity of three advanced two-dimensional nanomaterials (TDNMs), in combination with an organic chemical (3,4-dichloroaniline, DCA) to two freshwater microalgae (Scenedesmus obliquus and Chlorella pyrenoidosa), was assessed and predicted not only from classical mixture theory but also from structure-activity relationships. The TDNMs included two layered double hydroxides (Mg-Al-LDH and Zn-Al-LDH) and a graphene nanoplatelet (GNP). The toxicity of DCA varied with the type and concentration of TDNMs, as well as the species. The combination of DCA and TDNMs exhibited additive, antagonistic, and synergistic effects. There is a linear relationship between the different levels (10, 50, and 90%) of effect concentrations and a Freundlich adsorption coefficient (KF) calculated by isotherm models and adsorption energy (Ea) obtained in molecular simulations, respectively. The prediction model incorporating both parameters KF and Ea had a higher predictive power for the combined toxicity than the classical mixture model. Our findings provide new insights for the development of strategies aimed at evaluating the ecotoxicological risk of NMs towards combined pollution situations.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An Insight into the Combined Toxicity of 3,4-Dichloroaniline with Two-Dimensional Nanomaterials: From Classical Mixture Theory to Structure-Activity Relationship

Wang

2023

IJMS

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“…Size and surface potential affect the biological safety, distribution and transport process of nanomaterials. Studies have shown that the toxicity of nanomaterials increases with the decrease of particle size (< 100 nm), while oversized particles (> 10 μm) have the risk of microvascular embolism [ 46 – 48 ]. HE staining results showed no obvious histopathological changes in the main organs of the mice (Additional file 1 : Fig.…”

Section: Resultsmentioning

confidence: 99%

Photoacoustic mediated multifunctional tumor antigen trapping nanoparticles inhibit the recurrence and metastasis of ovarian cancer by enhancing tumor immunogenicity

Zhong

Zhao

et al. 2022

J Nanobiotechnol

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The hypoimmunogenicity of tumors is one of the main bottlenecks of cancer immunotherapy. Enhancing tumor immunogenicity can improve the efficacy of tumor immunotherapy by increasing antigen exposure and presentation, and establishing an inflammatory microenvironment. Here, a multifunctional antigen trapping nanoparticle with indocyanine green (ICG), aluminum hydroxide (Al(OH)3) and oxaliplatin (OXA) (PPIAO) has been developed for tumor photoacoustic/ultrasound dual-modality imaging and therapy. The combination of photothermal/photodynamic therapy and chemotherapy induced tumor antigen exposure and release through immunogenic death of tumor cells. A timely capture and storage of antigens by aluminum hydroxide enabled dendritic cells to recognize and present those antigens spatiotemporally. In an ovarian tumor model, the photoacoustic-mediated PPIAO NPs combination therapy achieved a transition from “cold tumor” to “hot tumor” that promoted more CD8+ T lymphocytes activation in vivo and intratumoral infiltration, and successfully inhibited the growth of primary and metastatic tumors. An in situ tumor vaccine effect was produced from the treated tumor tissue, assisting mice against the recurrence of tumor cells. This study provided a simple and effective personalized tumor vaccine strategy for better treatment of metastatic and recurrent tumors. The developed multifunctional tumor antigen trapping nanoparticles may be a promising nanoplatform for integrating multimodal imaging monitoring, tumor treatment, and tumor vaccine immunotherapy.

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“…In practice, the projected increased use and inevitable environmental release of various MNPs will result in ecosystems being subject to a wide range of mixtures of MNPs in varying compositions and varying concentrations. , Therefore, this study contributes important insights to better understand the bioaccumulation of MNPs via the food chain and the associated environmental risks under a more realistic exposure scenario. Our findings showed large variations in the MNPs’ transfer from plants to consumers.…”

Section: Discussionmentioning

confidence: 99%

Toxicokinetics and Particle Number-Based Trophic Transfer of a Metallic Nanoparticle Mixture in a Terrestrial Food Chain

Sun

Bosker

et al. 2023

Environ. Sci. Technol.

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Herein, we investigated to which extent metallic nanoparticles (MNPs) affect the trophic transfer of other coexisting MNPs from lettuce to terrestrial snails and the associated tissue-specific distribution using toxicokinetic (TK) modeling and single-particle inductively coupled plasma mass spectrometry. During a period of 22 days, snails were fed with lettuce leaves that were root exposed to AgNO 3 (0.05 mg/L), AgNPs (0.75 mg/L), TiO 2 NPs (200 mg/L), and a mixture of AgNPs and TiO 2 NPs (equivalent doses as for single NPs). The uptake rate constants (k u ) were 0.08 and 0.11 kg leaves/kg snail/d for Ag and 1.63 and 1.79 kg leaves/kg snail/d for Ti in snails fed with NPs single-and mixture-exposed lettuce, respectively. The elimination rate constants (k e ) of Ag in snails exposed to single AgNPs and mixed AgNPs were comparable to the corresponding k u , while the k e for Ti were lower than the corresponding k u . As a result, single TiO 2 NP treatments as well as exposure to mixtures containing TiO 2 NPs induced significant biomagnification from lettuce to snails with kinetic trophic transfer factors (TTF k ) of 7.99 and 6.46. The TTF k of Ag in the single AgNPs treatment (1.15 kg leaves/kg snail) was significantly greater than the TTF k in the mixture treatment (0.85 kg leaves/kg snail), while the fraction of Ag remaining in the body of snails after AgNPs exposure (36%) was lower than the Ag fraction remaining after mixture exposure (50%). These results indicated that the presence of TiO 2 NPs inhibited the trophic transfer of AgNPs from lettuce to snails but enhanced the retention of AgNPs in snails. Biomagnification of AgNPs from lettuce to snails was observed in an AgNPs single treatment using AgNPs number as the dose metric, which was reflected by the particle number-based TTFs of AgNPs in snails (1.67, i.e., higher than 1). The size distribution of AgNPs was shifted across the lettuce-snail food chain. By making use of particle-specific measurements and fitting TK processes, this research provides important implications for potential risks associated with the trophic transfer of MNP mixtures.

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Review and Prospects on the Ecotoxicity of Mixtures of Nanoparticles and Hybrid Nanomaterials

Cited by 50 publications

References 90 publications

An Insight into the Combined Toxicity of 3,4-Dichloroaniline with Two-Dimensional Nanomaterials: From Classical Mixture Theory to Structure-Activity Relationship

An Insight into the Combined Toxicity of 3,4-Dichloroaniline with Two-Dimensional Nanomaterials: From Classical Mixture Theory to Structure-Activity Relationship

Photoacoustic mediated multifunctional tumor antigen trapping nanoparticles inhibit the recurrence and metastasis of ovarian cancer by enhancing tumor immunogenicity

Toxicokinetics and Particle Number-Based Trophic Transfer of a Metallic Nanoparticle Mixture in a Terrestrial Food Chain

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