Review and Outlook of Stem Cell Transplantation for Neonatal Hypoxic- Ischemic Encephalopathy

Abstract

Abstract. Purpose:To research the states and feasibility of stem cells for neonatal hypoxic ischemic encephalopathy (HIE). Methods: In this study, "newborn, hypoxic ischemic encephalopathy, pathogenesis, stem cell transplantation" as the key words, which are searched the papers published in CNKI database and PubMed from January 1984 to December 2016.The efficacy of stem cell for neonatal HIE in animal and clinical trials are reviewed. Results: There are three types of stem cells for neonatal HIE including neural stem cells, mesenchymal stem cells and umbilical cord blood mononuclear stem cells. The methods and delivery routes of stem cell transplantation include intracerebra, intrathecal, peripheral intravascular and intranasal delivery. A large number of animal experiments have shown that stem cell for neonatal HIE may promote the differentiation and proliferation of endogenous stem cells, reduce the apoptosis of damaged brain tissue and improve the neurobehavioral function of animals. Clinical trials have shown that stem cell for neurological deficits in neonates with HIE has been significantly improved. Conclusions: Stem cell transplantation for neonatal HIE is a promising method, but some problems need to be solved urgently.