Review, analysis, and education of antiseptic related ocular injury in the surgical settings

Liu, Jen-Yu; Chu, Hsiao-Sang; Wei, Yi‐Hsuan; Cheng, Chia-Yi; Tsui, Mei‐Chi; Wu, Jo‐Hsuan; Huang, Wei‐Lun; Liu, Hsin‐Yu; Hou, Yu-Chih; Wang, I‐Jong; Hu, Fung‐Rong; Chen, Wei-Li

doi:10.1016/j.jtos.2021.06.011

Cited by 6 publications

(16 citation statements)

References 125 publications

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“…Regular use of disinfectants and hand sanitizers is also recommended for the prevention of COVID-19, although the hypochlorous acid and alcohol compounds contained therein could lead to concentration-dependent corneal and limbal toxicity, including superficial epithelial denudation, topical inflammation, and stem cell deficiency ( 61 , 62 ). Both direct and indirect contact through the volatilization of disinfectant components in the air could induce ocular inflammation, especially in patients with chronic allergies, compromised ocular surfaces, and previous ocular surface diseases like dry eyes ( 63 ).…”

Section: Resultsmentioning

confidence: 99%

COVID-19 Changed Prevalence, Disease Spectrum and Management Strategies of Ocular Trauma

Zhao

et al. 2022

Front. Med.

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The coronavirus disease 2019 (COVID-19) pandemic has significantly impacted the health of people around the world and has reshaped social behaviors and clinical practice. The purpose of this perspective is to provide epidemiologists and clinicians with information about how the spectrum of ocular trauma diseases changed, as well as to optimize management for improving patient prognosis during this crisis. Analysis of current studies revealed that the prevalence of eye trauma decreased overall, with a trend of delayed medical treatment during the COVID-19 era. Irregular epidemic prevention and control measures, unprotected home activities, and unusual mental states are the main causes of ocular trauma. Strategies for reducing morbidity are also discussed, including popularizing the use norms of prevention and control supplies, taking heed to the safety of family activities, highlighting the special status of child protection, and paying attention to previous case data to implement region-specific precautions. The procedure of ophthalmological emergency and outpatient management should also be optimized, and mental health should be emphasized during this pandemic.

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Section: Resultsmentioning

confidence: 99%

COVID-19 Changed Prevalence, Disease Spectrum and Management Strategies of Ocular Trauma

Zhao

et al. 2022

Front. Med.

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“…Chlorhexidine is a highly efficient skin antiseptic for surgical procedures 4 . It has been extensively used for skin preparation since the 1950s and is available in various concentrations, ranging from 0.5% to 4% 7 . Despite its widespread use, chlorhexidine carries potential risks 5,7,8 .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…Another commonly used skin preparation is a 10% povidone-iodine solution, which has been in use for over 150 years since the discovery of iodine in 1811 7,10 . In this water-soluble compound, iodine forms a complex with povidone or polyvinylpyrrolidone 7 . The bactericidal efficacy of this solution is directly correlated with the concentration of free iodine, which acts as the principal bactericidal component 10 .…”

Section: Discussionmentioning

confidence: 99%

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Chemical Burn Injury on the Cornea Following Skin Preparation With Chlorhexidine in Tonsillectomy and Adenoidectomy

Oh,

Kim,

Heo

2023

Journal of Craniofacial Surgery

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This article report discusses a pediatric patient who suffered a corneal chemical burn injury after tonsillectomy and adenoidectomy surgery due to skin preparation with chlorhexidine. In this case, inadequate sealing of the eye shield during skin preparation allowed the chlorhexidine–alcohol solution to accumulate at its edge and gradually penetrate, resulting in the corneal injury. Prompt ophthalmological intervention and appropriate eye care treatment led to a gradual improvement in the patient’s symptoms. The authors aim to present the case, share the revisions made to our skin preparation policy, and emphasize the importance of cautious antiseptic use to minimize the risk of adverse events. Adverse effects of chlorhexidine, such as hypersensitivity reactions and burns, including corneal damage, are highlighted. Health care providers should exercise caution when selecting and applying antiseptics, considering patient-specific factors, and comprehensive training should be provided to promote adherence to safe antiseptic practices during surgical procedures.

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“…In a 3-month trial, chlorhexidine-based toothpaste (0.12%, twice daily brushing, n = 20) was associated with burning sensation in two patients and one patient had severe upper palatal tooth staining ( Cosola et al, 2021 ) [c]. Chlorhexidine can be toxic to the ocular surface, so that based on a review of the literature the prohibition of this compound in solutions intended for contact with the eyes and other membranes has been advised ( Liu, Chu, et al, 2021 ) [R]. In a review of antimicrobial data going back to the 1940s, some strains including Pseudomonas aeruginosa , Klebsiella pneumoniae and Acinetobacter baumannii were detected to exhibit increased resistance to chlorhexidine ( Buxser, 2021 ) [M].…”

Section: Guanidinesmentioning

confidence: 99%

Antiseptic drugs and disinfectants with experience of the second year of COVID-19 pandemic-related side effects

Lachenmeier

2022

Side Effects of Drugs Annual

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Review, analysis, and education of antiseptic related ocular injury in the surgical settings

Cited by 6 publications

References 125 publications

COVID-19 Changed Prevalence, Disease Spectrum and Management Strategies of Ocular Trauma

COVID-19 Changed Prevalence, Disease Spectrum and Management Strategies of Ocular Trauma

Chemical Burn Injury on the Cornea Following Skin Preparation With Chlorhexidine in Tonsillectomy and Adenoidectomy

Antiseptic drugs and disinfectants with experience of the second year of COVID-19 pandemic-related side effects

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