Review: an overview of recent developments in coordination chemistry of polypyrazolylmethylamines. Complexes with N-scorpionate ligands createdin situfrom pyrazole derivatives and zerovalent metals

Selective Cytotoxicity of Complexes with N,N,N-Donor Dipodal Ligand in Tumor Cells

“…This multipodal, tridentate organic ligand formed in situ can be called an "impaired" scorpionate, an analogue of poly(pyrazolyl)borate ligands, containing only two, instead of three, pyrazole groups. Generally, complexes with an N,N-bis(3,5-dimethylpyrazol-1-ylmethyl)amine (L D ) ligand are much less numerous than those with tripodal teradentate ligands [16,18,19,22]. Only nine complexes with N,N-bis(3,5-dimethylpyrazol-1-ylmethyl)amine have been reported in CCDC, and therein six complexes were synthesised by us [16,18,19,21,22].…”

“…We have previously reported the one pot synthesis and physicochemical characterizations of complexes containing N,N,N-tris (3.5-dimethylpyrazol-1-ylmethyl)amine ligands (L S ) [6,[13][14][15][16], which is an analogue of original poly(pyrazol-1-yl) borates called scorpionates [17]. Complexes with N,N,N-tris(3.5-dimethylpyrazol-1-ylmethyl)amine ligands (L S ) showed high antiproliferative activities against a panel of human cancer cells [6,15,16]. The nature of ligands and their architectures significantly determines the properties of resulting complex species [6,[13][14][15][16][18][19][20][21].We have also previously found that cationic-anionic (Co/Zn and Co/Cd) complexes containing N-scorpionate ligands (such as N,N,N-tris (3.5-dimethylpyrazol-1-ylmethyl)amine (L S )), express substantial antiproliferative potency [6,15].…”

“…Complexes with N,N,N-tris(3.5-dimethylpyrazol-1-ylmethyl)amine ligands (L S ) showed high antiproliferative activities against a panel of human cancer cells [6,15,16]. The nature of ligands and their architectures significantly determines the properties of resulting complex species [6,[13][14][15][16][18][19][20][21].We have also previously found that cationic-anionic (Co/Zn and Co/Cd) complexes containing N-scorpionate ligands (such as N,N,N-tris (3.5-dimethylpyrazol-1-ylmethyl)amine (L S )), express substantial antiproliferative potency [6,15]. The cytotoxic evaluation of these complexes also revealed their high selectivity for cancer cells.…”

“…The identification of structural properties of metal-based complexes that may augment their antitumour activities is the sole basis of designing novel potent complexes. We have previously reported the one pot synthesis and physicochemical characterizations of complexes containing N,N,N-tris (3.5-dimethylpyrazol-1-ylmethyl)amine ligands (L S ) [ 6 , 13 , 14 , 15 , 16 ], which is an analogue of original poly(pyrazol-1-yl) borates called scorpionates [ 17 ]. Complexes with N,N,N-tris(3.5-dimethylpyrazol-1-ylmethyl)amine ligands (L S ) showed high antiproliferative activities against a panel of human cancer cells [ 6 , 15 , 16 ].…”

Imidazole‐Bridged Tetrameric Group(IV) Heteroleptic Complexes from the Spontaneous Metal‐Ligand Assembly of a Potentially N4‐Tetradentate Ligand

“…To this aim, significant efforts have been devoted to tailor electronic and steric ligands properties and to accommodate various metal ions in their binding pockets as to prepare organometallics or coordination compounds featured by targeted catalytic requirements . In particular, the preparation of multidentate N‐ligands (N > 2) and the study of their metal ion coordination behavior is a well‐developed research area in contemporary organometallic chemistry . The introduction of aromatic N‐containing heterocycles like pyridine, triazole, or pyrazole, has contributed to expand the variety of N‐multidentate backbones.…”