Review &amp; meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms – an update on the evidence

Castelo-Branco, Camil; Gambacciani, Marco; Cano, Antonio; Minkin, Mary Jane; Rachoń, Dominik; Ruan, Xiaoli; Am, Beer; Schnitker, J; Zepelin, Hans-Heinrich Henneicke-von; Pickartz, S.

doi:10.1080/13697137.2020.1820477

Cited by 30 publications

(26 citation statements)

References 81 publications

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“…The effect of the isopropanol extract can be compared even with low doses of transdermal estradiol or tibolone and has a better benefit-risk profile than tibolone [25]. Few side effects occurred, which were not more severe than in the placebo group, and no hepatotoxic effects were observed [23].…”

Section: Resultsmentioning

confidence: 98%

“…Based on these results, it can be concluded that the benefits of using black cohosh extract or a combination of black cohosh extract and St. John's wort outweigh the risks, so that their use is recommended for the treatment of menopausal symptoms [23], including in patients with hormone-dependent disorders [26,27].…”

Section: Resultsmentioning

confidence: 99%

“…Castelo-Branco and coworkers, in a systematic review of the literature, found 35 clinical trials and one meta-analysis involving 43,759 women, 13,096 of whom were treated with an isopropanol extract of black cohosh [23]. Based on these data, it was found that both neurovegetative and psychological menopausal symptoms were significantly less pronounced when the extract was used than in the group of women who did not receive it.…”

Section: Resultsmentioning

confidence: 99%

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Herbal Products Used in Menopause and for Gynecological Disorders

et al. 2021

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Herbal products are often used as an alternative to pharmacological therapy. Menopausal symptoms and gynecological disorders (such as premenstrual syndrome and dysmenorrhea) are the indications where pharmacological therapy may have serious adverse events, hence many women prefer to use herbal products to help with these symptoms. Here, we reviewed plants and derived products, which are commonly used for the abovementioned indications, focusing on clinical data, safely profile and whether or not their use is justified. We noted that limited data are available on the use of some plants for alleviating the symptoms of menopause and gynecological disorders. While black cohosh (Cimicifuga racemose) and red clover (Trifolium pretense) were consistently shown to help reduce menopausal symptoms in clinical studies, currently available data do not fully support the use of fenugreek (Trigonella foenum-graecum), hops (Humulus lupulus), valerian (Valeriana officinalis), and soybean (Glycine max and Glycine soja) for this indication. For premenstrual syndrome and premenstrual dysphoric disorder, chaste tree (Vitex agnus-castus) shows effectiveness, but more clinical studies are needed to confirm such effect upon the use of evening primrose (Oenothera biennis).

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Section: Resultsmentioning

confidence: 98%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Herbal Products Used in Menopause and for Gynecological Disorders

et al. 2021

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“…Now, a new systematic review of isopropanolic black cohosh identified 35 eligible clinical studies which compared the root extract with placebo and found it ‘significantly superior for treating neurovegetative and psychological menopausal symptoms’, with a standardised mean difference of −0.694 in its favour. 1…”

Section: Significant Recommendations For Black Cohosh In New Meta-analysismentioning

confidence: 99%

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Brown¹

2021

Post Reprod Health

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“…Сухой экстракт корневищ цимицифуги (Cimicifuga racemosa) -одно из самых применяемых растений в фитотерапии при лечении приливов жара. Экстракт Cimicifuga racemosa не взаимодействует с рецепторами к эстрогену, а действует через рецепторы серотонина, дофамина и норадреналина в головном мозге [13]. Систематический обзор, опубликованный в 2021 году, объединил 35 клинических исследований и один метаанализ с участием 43 759 женщин, из которых 13 096 получали экстракт Cimicifuga racemosa.…”

Section: обзорыunclassified

Симидона Форте - Эффективное Негормональное Лечение Климактерических Расстройств

Грудницкая¹,

Кучура²

2021

Репродуктивное Здоровье. Восточная Европа

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В статье проанализированы данные 26-го издания Организации Объединенных Наций очисленности и возрастной структуре народонаселения мира. Отмечено беспрецедентное старение населения в связи с увеличением продолжительности жизни. Поэтому ожидается, что с каждым годом будет увеличиваться количество женщин, нуждающихся в оказании медицинской помощи в связи с симптомами менопаузы, так как треть своей жизни они будут проводить в условиях дефицита эстрогенов. Раннее купирование вазомоторных симптомов и стабилизация массы тела рассматриваются как стратегия терапии женщин в менопаузе. Рассматривается альтернатива менопаузальной гормональной терапии - лечение растительным экстрактом Cimicifuga racemosa Zе 450 (торговое название в Республике Беларусь - Симидона, Британская компания Amaxa LTD), который продемонстрировал эффективное купирование вазомоторных симптомов и стабилизирующее влияние на массу тела и метаболические параметры у женщин в период менопаузы. The article analyzes the data of the 26th edition of the United Nations on the number and age structure of the world population. There is an unprecedented aging of the population due to an increase in life expectancy. Therefore, it is expected that the number of women who need medical care due to menopause symptoms will increase every year, since they will spend a third of their lives in conditions of estrogen deficiency. Early relief of vasomotor symptoms and stabilization of body weight is considered as a therapy strategy for menopausal women. An alternative to menopausal hormone therapy is considered-treatment with a plant extract of Cimicifuga racemosa Ze 450, which has demonstrated effective relief of vasomotor symptoms and a stabilizing effect on body weight and metabolic parameters in menopausal women.

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Review & meta-analysis: isopropanolic black cohosh extract iCR for menopausal symptoms – an update on the evidence

Cited by 30 publications

References 81 publications

Herbal Products Used in Menopause and for Gynecological Disorders

Herbal Products Used in Menopause and for Gynecological Disorders

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Симидона Форте - Эффективное Негормональное Лечение Климактерических Расстройств

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