“…In melanoma, alterations of a2b1, a3b1, and a6b1 integrins appear to be associated with malignancy (Chen et al, 1991;Natali et al, 1991Natali et al, ,1993Moretti et al, 1993). In breast cancer, a2b1, a5b1, or a6b4 integrins seem to be crucial for malignant transformation (Pignatelli et al, 1991;Natali et al, 1992;Zutter et al, 1993;Weaver et al, 1997). In pancreatic carcinoma cell lines, expression of a2, a3, a6, b1, b4, and b5 integrins was detected in adenocarcinomas and ampullary tumours, in the normal pancreas, reduced levels of expression occur, or in the case of some integrins there is no expression (Hall et al, 1991).…”