1979
DOI: 10.1016/0027-5107(79)90100-3
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Reversion of nonsense mutants induced by 4-nitroquinoline-1-oxide in Schizosaccharomyces pombe

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1979
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Cited by 6 publications
(5 citation statements)
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“…Therefore 4-NQO mutagenesis can cause all possible single-nucleotide substitutions. In previous 4-NQO mutagenesis studies using tester strains, mutations of adenine were reported as either absent ( Prakash et al 1974 ) or low-frequency events (~7%) and were only significantly different to nonmutagenized control strains in three of six experiments ( Janner et al 1979 ). We found only one occurrence of a deletion and no insertions.…”
Section: Resultsmentioning
confidence: 90%
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“…Therefore 4-NQO mutagenesis can cause all possible single-nucleotide substitutions. In previous 4-NQO mutagenesis studies using tester strains, mutations of adenine were reported as either absent ( Prakash et al 1974 ) or low-frequency events (~7%) and were only significantly different to nonmutagenized control strains in three of six experiments ( Janner et al 1979 ). We found only one occurrence of a deletion and no insertions.…”
Section: Resultsmentioning
confidence: 90%
“…4-NQO was previously reported to induce transitions or transversions of guanine residues and frameshifts in bacteria and yeasts ( Prakash et al 1974 ; Janner et al 1979 ; Rosenkranz and Poirier 1979 ). However, adducts of adenine are also formed and therefore adenine is a possible target ( Galiègue-Zouitina et al 1984 , 1985 ; Bailleul et al 1989 ; Menichini et al 1989 ).…”
Section: Resultsmentioning
confidence: 99%
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“…A number of methods have been used to effect DNA damage in yeasts. Double strand breaks can be generated by expression of site-specific endonucleases such as HO [4] , [5] and I-SceI [6] , exposure to chemical agents such as bleomycin-family antibiotics [7] or 4-NQO [8] , or using γ or UV-C irradiation [9] . A wide range of chemical agents can effect nucleotide damage, such as the DNA methylating agent MMS, which generates lesions including N3-methyl adenine that cannot be bypassed by replicative DNA polymerases [10] , potentially leading to fork stalling and collapse.…”
Section: Introductionmentioning
confidence: 99%