Reversion of Nitrate Tolerance in Rat Aorta Rings by Freeze‐dried Red Wine

Fusi, Fabio; Sgaragli, Gian Pietro

doi:10.1002/ptr.5287

Cited by 3 publications

(2 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, it has been shown that nitrate tolerance, due to oxidation of the sulfhydryl groups present in the active site of ALDH2 (specifically the oxidation of cysteine 302, which is the critical catalytic amino acid of ALDH2 [ 106 ]), may not develop due to the pre-administration of lipoic acid, which can prevent or modify the oxidative inhibition of the enzyme. In fact, within the mitochondria, lipoic acid is enzymatically reduced to dihydrolipoic acid, which is capable of reducing the disulfides at the ALDH2 active site [ 118 ]. Furthermore, in vitro studies conducted on rat aorta rings have shown that freeze-dried (dealcoholized) red wine (FDRW), due to its polyphenol content, may be partially effective against GTN tolerance.…”

Section: Treatment Of Nitrate Tolerancementioning

confidence: 99%

The Generation of Nitric Oxide from Aldehyde Dehydrogenase-2: The Role of Dietary Nitrates and Their Implication in Cardiovascular Disease Management

Maiuolo

Oppedisano²,

Carresi³

et al. 2022

IJMS

View full text Add to dashboard Cite

Reduced bioavailability of the nitric oxide (NO) signaling molecule has been associated with the onset of cardiovascular disease. One of the better-known and effective therapies for cardiovascular disorders is the use of organic nitrates, such as glyceryl trinitrate (GTN), which increases the concentration of NO. Unfortunately, chronic use of this therapy can induce a phenomenon known as “nitrate tolerance”, which is defined as the loss of hemodynamic effects and a reduction in therapeutic effects. As such, a higher dosage of GTN is required in order to achieve the same vasodilatory and antiplatelet effects. Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is a cardioprotective enzyme that catalyzes the bio-activation of GTN to NO. Nitrate tolerance is accompanied by an increase in oxidative stress, endothelial dysfunction, and sympathetic activation, as well as a loss of the catalytic activity of ALDH2 itself. On the basis of current knowledge, nitrate intake in the diet would guarantee a concentration of NO such as to avoid (or at least reduce) treatment with GTN and the consequent onset of nitrate tolerance in the course of cardiovascular diseases, so as not to make necessary the increase in GTN concentrations and the possible inhibition/alteration of ALDH2, which aggravates the problem of a positive feedback mechanism. Therefore, the purpose of this review is to summarize data relating to the introduction into the diet of some natural products that could assist pharmacological therapy in order to provide the NO necessary to reduce the intake of GTN and the phenomenon of nitrate tolerance and to ensure the correct catalytic activity of ALDH2.

show abstract

Section: Treatment Of Nitrate Tolerancementioning

confidence: 99%

The Generation of Nitric Oxide from Aldehyde Dehydrogenase-2: The Role of Dietary Nitrates and Their Implication in Cardiovascular Disease Management

Maiuolo

Oppedisano²,

Carresi³

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…Numerous studies have suggested that higher consumption of fruits and vegetables may lower the incidence of CVD, owing to the large amount of polyphenols and flavonoids, which favor antioxidant activity (Fusi and Sgaragli, ; Ivanova et al , ). Epidemiological evidence has shown intake of red wine will improves lipoprotein metabolism and lowers cardiovascular risk because it contains both polyphenols (phenolic acids and flavonoids) and alcohol (Costanzo et al , ).…”

Section: Introductionmentioning

confidence: 99%

Cardioprotective Efficacy of Red Wine Extract of Onion in Healthy Hypercholesterolemic Subjects

Chiu

Shen

Huang

et al. 2015

Phytotherapy Research

View full text Add to dashboard Cite

The objective of this study was to evaluate the efficacy of the red wine extract of onion (RO) and red wine (RW) on alleviating the risk factors of cardiovascular disease. During in vitro studies, various antioxidant activities [trolox equivalent antioxidant capacity (TEAC), DPPH, and H2 O2 scavenging ability] of RO and RW group were evaluated. Both RO and RW showed the maximum antioxidant capacity. During in vivo studies, 23 healthy hypercholesterolemic volunteers were randomly selected and assigned into two groups, who drunk 250 mL of RO (n = 11) or RW (n = 10) for 10 weeks. No significant changes were observed in anthropometric parameters (body weight, height, body mass, and BMI) in each group. Both RW and RO extracts elevated (p < 0.05) antioxidant activity and thereby prolonging the lag time of low-density lipoprotein oxidation. However, RO extract intake substantially suppressed (p < 0.05) the total cholesterol and low-density lipoprotein cholesterol levels when equivalence with RW thus, indicating its additional hypocholesterolemic effect. The inflammatory markers such as factor VII were also positively modulated by RO extract. Results indicated that RO extract consumption rendered better cardio protective effect than RW by altering cholesterol, improving antioxidation and suppressing inflammatory marker levels and thereby, attenuating the cardiovascular disease incidence.

show abstract

Recent advances in polyphenols improving vascular endothelial dysfunction induced by endogenous toxicity

Fei

Wang

2020

J of Applied Toxicology

View full text Add to dashboard Cite

Endothelial dysfunction is the early marker and precursor for the development of a series of vascular disease. Epidemiologic and experimental evidences have suggested that regular consumptions of polyphenol rich extracts or individual phenolic compounds both improve endothelial function. The present review concludes the recent advances in the protective effects of polyphenol‐rich extracts and individual phenolic compounds on the endothelial function. The vascular protective benefits of polyphenol have been well established with so many in vitro and in vivo studies. The mechanisms underlying the protection actions have also been elucidated much. Further studies may lay efforts on understanding the controversies among results from different assays, exploring deeper and more comprehensive mechanisms, elaborating the structure–activity relationship, and improving the safety evaluation research.

show abstract

Reversion of Nitrate Tolerance in Rat Aorta Rings by Freeze‐dried Red Wine

Cited by 3 publications

References 16 publications

The Generation of Nitric Oxide from Aldehyde Dehydrogenase-2: The Role of Dietary Nitrates and Their Implication in Cardiovascular Disease Management

The Generation of Nitric Oxide from Aldehyde Dehydrogenase-2: The Role of Dietary Nitrates and Their Implication in Cardiovascular Disease Management

Cardioprotective Efficacy of Red Wine Extract of Onion in Healthy Hypercholesterolemic Subjects

Recent advances in polyphenols improving vascular endothelial dysfunction induced by endogenous toxicity

Contact Info

Product

Resources

About