Reversing neuromuscular blocking agent decamethonium by carboxylatopillar[6]arene based on host-guest encapsulation

Host–Guest Formulation of Carboxylatopillar[6]arene with Ergothioneine as a New Antidote for Combinational Detoxification of Paraquat

“…Prior to biological activity analysis, the cytotoxicity of EGT/CP6A was evaluated in human alveolar epithelial (BEAS-2B) cell lines, normal human hepatic (LO2) cell lines, and human normal renal epithelial (293T) cell lines using a standard Cell Counting Kit-8 (CCK-8) assay method. Our group reported that CP6A displayed minimal cytotoxicity and low system cytotoxicity, , and the previous studies confirmed that EGT has excellent biocompatibility. − As shown in Figure S5, even at relatively high concentrations, EGT/CP6A displayed minimal cytotoxicity against these cell lines. The change in mice’s body weight was monitored as another evidence to verify the low system toxicity of EGT/CP6A.…”

“…Upon addition of one equivalent of CP6A, the proton signals of EGT (H b , H c and H d ) underwent substantial upfield shifts and broadening compared to free EGT, presumably as a consequence of the inclusion-induced shielding effect. 37,48 The proton signal of H 1 and H 2 in CP6A underwent an upfield shift owing to the effect of electrostatic interactions. A similar phenomenon was observed in other host−guest systems.…”

Host–guest binding of tetracationic cyclophanes to photodynamic agents inhibits posttreatment phototoxicity and maintains antitumour efficacy

“…This sequestration strategy has witnessed a major advance in the clinical use of Sugammadex, a γ-cyclodextrin-derived macrocycle, in binding rocuronium and vecuronium to reverse their residue neuromuscular blockade. 24 In the past decade, calixarene, [25][26][27][28] (acyclic) cucurbituril [29][30][31][32][33] and pillararene [34][35][36][37] derivatives have been investigated as supramolecular hosts for binding different drugs or toxicants. [38][39][40] However, to the best of our knowledge, the potential of rigid tetracationic cyclophanes for drug sequestration and clearance has not yet been explored.…”

Separation of Low-Molecular-Weight Organics by Water-Soluble Macrocyclic Arenes

“…Their size-specific electron-rich hydrophobic cavities can selectively bind certain molecules through host–guest interactions [ 26 , 27 , 28 ]. The host–guest properties of macrocycles have been extensively applied in the fields of drug delivery [ 29 , 30 , 31 ], water purification [ 32 ], self-assembly [ 33 ], photochromism [ 34 , 35 ], and substance detection [ 36 , 37 , 38 , 39 ]. In particular, the development of pillararene-based macrocyclic arenes has increased rapidly since they were first reported on in 2008, and a variety of expanded versions of macrocyclic arenes, such as leaning pillar[6]arene [ 40 ], biphenyl-extended pillar[6]arene [ 41 ], geminiarenes [ 42 ], leggero pillar[5]arene [ 43 ], and hybrid [n] arenes [ 44 ], have been synthesized.…”