Reversing dobutamine‐induced tachycardia using ivabradine increases stroke volume with neutral effect on cardiac energetics in left ventricular post‐ischaemia dysfunction

Abstract

A combined infusion of dobutamine and ivabradine had a neutral effect on post-ischaemia LV efficiency and increased left ventricular output without an increase in HR.

Ivabradine in acute heart failure: Effects on heart rate and hemodynamic parameters in a randomized and controlled swine trial

“…In one experimental swine model, Bakkehaug et al [25] presented an ischemia-reperfusion protocol in 12 pigs after intermittent ligation of the left coronary arteries. Dobutamine infusion in post-ischemic heart increased CO by increasing significantly HR from 102 to 131 bpm (p < 0.05).…”

Does ivabradine balance dobutamine effects in cardiogenic shock? A promising new strategy

“…In conclusion, results presented in the paper of Bakkehaug et al . () are promising and have to be confirmed by a clinical study to assess the effect of this strategy in the aim to counteract deleterious effects of dobutamine in patients with CS all the more as we lack data and because of poor outcomes in this setting.…”

“…In the study published in this journal, Bakkehaug et al . () reported a basic model of CS (Bakkehaug et al . ).…”

“…Bakkehaug et al . () proposed a double approach to assess the effects of this pure negative chronotropic drug without inotropic depression in the context of CS:…”

Current matters of the heart

“…In a pre‐diabetic animal model, fibroblast growth factor 21 therapy improved LV function and metabolic symptoms . Post‐ischaemic LV dysfunction could be improved by a combined therapeutic inotropic support (dobutamine) and selective heart rate reduction (ivabradine) …”