Reversing and modulating cellular senescence in beta cells, a new field of opportunities to treat diabetes
Maria F. Rubin de Celis,
Susan Bonner-Weir
Abstract:Diabetes constitutes a world-wide pandemic that requires searching for new treatments to halt its progression. Cellular senescence of pancreatic beta cells has been described as a major contributor to development and worsening of diabetes. The concept of reversibility of cellular senescence is critical as is the timing to take actions against this “dormant” senescent state. The reversal of cellular senescence can be considered as rejuvenation of the specific cell if it returns to the original “healthy state” a… Show more
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