Reversibly Photoswitching Upconversion Nanoparticles for Super‐Sensitive Photoacoustic Molecular Imaging

Rao, Jianghong; Liu, Cheng; Zheng, Xianchuang; Dai, Tingting; Wang, Shuangfeng; Chen, Xian; Chen, Bing; Sun, Tianying; Wang, Feng; Chu, Steven

doi:10.1002/anie.202116802

Cited by 27 publications

(22 citation statements)

References 44 publications

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“…This probe significantly removed the background signal, and it (0.5 nm) was successfully deployed in hemoglobin solution, enhancing the S/N ratio and imaging sensitivity. [137] Only at lesion locations may activatable biomaterials be triggered by disease-related small molecules or disease microenvironment. [138][139][140] The creation of activatable imaging probes can efficiently minimize background signal and increase imaging sensitivity and specificity, which is particularly crucial for the identification of minute lesions.…”

Section: "Turn-on" Pa Imaging Probesmentioning

confidence: 99%

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Biomedical Photoacoustic Imaging for Molecular Detection and Disease Diagnosis: “Always‐On” and “Turn‐On” Probes

Zeng

Dou

et al. 2022

Advanced Science

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Photoacoustic (PA) imaging is a nonionizing, noninvasive imaging technique that combines optical and ultrasonic imaging modalities to provide images with excellent contrast, spatial resolution, and penetration depth. Exogenous PA contrast agents are created to increase the sensitivity and specificity of PA imaging and to offer diagnostic information for illnesses. The existing PA contrast agents are categorized into two groups in this review: “always‐on” and “turn‐on,” based on their ability to be triggered by target molecules. The present state of these probes, their merits and limitations, and their future development, is explored.

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Section: "Turn-on" Pa Imaging Probesmentioning

confidence: 99%

“…This probe significantly removed the background signal, and it (0.5 n m ) was successfully deployed in hemoglobin solution, enhancing the S/N ratio and imaging sensitivity. [ 137 ]…”

Section: “Turn‐on” Pa Imaging Probesmentioning

confidence: 99%

Biomedical Photoacoustic Imaging for Molecular Detection and Disease Diagnosis: “Always‐On” and “Turn‐On” Probes

Zeng

Dou

et al. 2022

Advanced Science

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“…The progressive development of such probes and parallel versions of them has been reviewed extensively. 241 Liu et al., 240 however, recently developed upconverting nanoprobes that were able to reversibly switch states with far-red and NIR excitation. These particles were demonstrated via labeled HeLa cells injected in mice and shown to have a 0.05-nM detection limit using differential imaging.…”

Section: Activatable Photoswitching and Temperature-dependent Photoac...mentioning

confidence: 99%

Looking deep inside tissue with photoacoustic molecular probes: a review

2022

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. Significance: Deep tissue noninvasive high-resolution imaging with light is challenging due to the high degree of light absorption and scattering in biological tissue. Photoacoustic imaging (PAI) can overcome some of the challenges of pure optical or ultrasound imaging to provide high-resolution deep tissue imaging. However, label-free PAI signals from light absorbing chromophores within the tissue are nonspecific. The use of exogeneous contrast agents (probes) not only enhances the imaging contrast (and imaging depth) but also increases the specificity of PAI by binding only to targeted molecules and often providing signals distinct from the background. Aim: We aim to review the current development and future progression of photoacoustic molecular probes/contrast agents. Approach: First, PAI and the need for using contrast agents are briefly introduced. Then, the recent development of contrast agents in terms of materials used to construct them is discussed. Then, various probes are discussed based on targeting mechanisms, in vivo molecular imaging applications, multimodal uses, and use in theranostic applications. Results: Material combinations are being used to develop highly specific contrast agents. In addition to passive accumulation, probes utilizing activation mechanisms show promise for greater controllability. Several probes also enable concurrent multimodal use with fluorescence, ultrasound, Raman, magnetic resonance imaging, and computed tomography. Finally, targeted probes are also shown to aid localized and molecularly specific photo-induced therapy. Conclusions: The development of contrast agents provides a promising prospect for increased contrast, higher imaging depth, and molecularly specific information. Of note are agents that allow for controlled activation, explore other optical windows, and enable multimodal use to overcome some of the shortcomings of label-free PAI.

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“…Inspired by the application of light in phototherapy, − clinically relevant ionizing radiation (X-ray, γ-ray, etc.) also has the potential to be a precise perturbing tool in living bodies as it features precision and deep tissue penetration (up to 15 cm). − In addition, although over 50% of cancer patients take radiotherapy, radiotherapy may fail because the total dose limitation (generally less than 60 Gy) and hypoxia resistance with oxygen are involved in the fixation of radiation-induced DNA damage .…”

Section: Introductionmentioning

confidence: 99%

Radiotherapy Reduces N-Oxides for Prodrug Activation in Tumors

et al. 2022

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Precisely activating chemotherapeutic prodrugs in a tumor-selective manner is an ideal way to cure cancers without causing systemic toxicities. Although many efforts have been made, developing spatiotemporally controllable activation methods is still an unmet challenge. Here, we report a novel prodrug activation strategy using radiotherapy (X-ray). Due to its precision and deep tissue penetration, X-ray matches the need for altering molecules in tumors through water radiolysis. We first demonstrated that Noxides can be effectively reduced by hydrated electrons (e − aq ) generated from radiation both in tubes and living cells. A screening is performed to investigate the structure−reduction relationship and mechanism of the e − aq -mediated reductions. We then apply the strategy to activate N-oxide prodrugs. The anticancer drug camptothecin (CPT)-based N-oxide prodrug shows a remarkable anticancer effect upon activation by radiotherapy. This radiation-induced in vivo chemistry may enable versatile designs of radiotherapy-activated prodrugs, which are of remarkable clinical relevance, as over 50% of cancer patients take radiotherapy.

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Reversibly Photoswitching Upconversion Nanoparticles for Super‐Sensitive Photoacoustic Molecular Imaging

Cited by 27 publications

References 44 publications

Biomedical Photoacoustic Imaging for Molecular Detection and Disease Diagnosis: “Always‐On” and “Turn‐On” Probes

Biomedical Photoacoustic Imaging for Molecular Detection and Disease Diagnosis: “Always‐On” and “Turn‐On” Probes

Looking deep inside tissue with photoacoustic molecular probes: a review

Radiotherapy Reduces N-Oxides for Prodrug Activation in Tumors

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