Reversibly Altering Electronic Conduction through a Single Molecule by a Chemical Binding Event

Kasibhatla, B.; Labonté, André P.; Zahid, Ferdows; Reifenberger, R.; Datta, Supriyo; Kubiak, Clifford P.

doi:10.1021/jp036715g

Cited by 25 publications

(44 citation statements)

References 32 publications

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“…Thus, DTs electrochemical desorption can be better understood by making additional considerations, like the way that the DT molecules are bonded to the surface, and the interactions/bonds between DT molecules. Regarding the bonding of DT molecules to the surface, it gives origin to structures where DT molecules can present standing-up (Schemes 1d-j) [4][5][6][7] or lying-flat (Scheme 1k) [7][8][9][10] configuration. For the ideal DT (…”

Section: Background Concepts and Bibliographic Surveymentioning

confidence: 99%

See 1 more Smart Citation

Electrochemical study of adlayers of α,ω-alkanedithiols on Au(111): Influence of the forming solution, chain length and treatment with mild reducing agents

Cometto

Calderón

Euti

et al. 2011

Journal of Electroanalytical Chemistry

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Section: Background Concepts and Bibliographic Surveymentioning

confidence: 99%

“…In particular, when these molecules have the same affinity to the surface to both ends (e.g. a,x-alkanedithiols), they could be adsorbed in an upright (mono-coordinated) [4][5][6][7] or a lying down configuration (bi-coordinated) [6][7][8][9][10] depending on the preparation method (UHV, solutions, etc.) and the surface coverage.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical study of adlayers of α,ω-alkanedithiols on Au(111): Influence of the forming solution, chain length and treatment with mild reducing agents

Cometto

Calderón

Euti

et al. 2011

Journal of Electroanalytical Chemistry

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“…[5] Alternatively, molecular switches can be operated nonconformationally by redox reactions [6] or a chemical binding event. [7] Biomolecules have recently been adapted for new purposes; for example, DNA has been used as part of a conducting wire, [8] a molecular machine, [9][10][11][12] a crystal template, [13] a scaffold for nanoscale construction, [14] and even as a component of a "computing machine". [15,16] Herein we show that the fluorescence of individual dye-labeled DNA molecules can be reversibly switched from green to red and vice versa upon application of an electric field.…”

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confidence: 99%

Individual Molecules of Dye‐Labeled DNA Act as a Reversible Two‐Color Switch upon Application of an Electric Field

et al. 2004

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Over the past few years, molecular switches have been heavily researched in the quest for molecular electronic devices. Some switching systems operate by a conformational change in the molecule which is induced by either an electric field, [1,2] an STM (scanning tunneling microscope) tip, [3] an electrochemical reaction, [4] or light. [5] Alternatively, molecular switches can be operated nonconformationally by redox reactions [6] or a chemical binding event. [7] Biomolecules have recently been adapted for new purposes; for example, DNA has been used as part of a conducting wire, [8] a molecular machine, [9][10][11][12] a crystal template, [13] a scaffold for nanoscale construction, [14] and even as a component of a "computing machine". [15,16] Herein we show that the fluorescence of individual dye-labeled DNA molecules can be reversibly switched from green to red and vice versa upon application of an electric field.The use of nucleic acids as molecular switches is a relatively new concept and, so far, has had limited success. The use of an electric field to modulate the fluorescence of labeled DNA adsorbed onto an electrode [17] and the use of a magnetic field to control the hybridization state of DNA [18] are known. Conformational switching of DNA by the variation of buffer conditions, [11,19] the binding of adenosine to an aptamer sequence on DNA, [20] or the binding of singlestranded DNA (ssDNA) to a DNA quadruplex [9] have also recently been reported. The main limitation with the current mechanisms for DNA conformational switches is that they require bimolecular hybridization or a change of buffer, thus switching is slow. Furthermore, in some cases switching is not reversible [20] or the process creates undesirable "waste" DNA. [9,10] Our DNA switch overcomes these problems by using an electric field to alter the DNA-dye interaction which renders the switching process rapid (< 100 ms) and reversible with no by-products.Here a controllable electric field and single-molecule fluorescence detection were used to probe the switching of the fluorescent states of individual DNA molecules that were labeled with two different fluorophores at the same end of the DNA duplex. We previously utilized the very high electricfield gradients generated at the tip of a nanopipette to controllably concentrate and deliver DNA. [21][22][23] The pipettes have an inner diameter of 100 nm and the voltage drop occurs in the last few microns of the tip owing to its tapered shape. By application of a potential of 1 V between the electrode in the bath and the electrode in the pipette, a very high electric field of % 8000 V cm À1 is generated at the tip of the pipette.[22]The fluorescence of both fluorophores was detected simultaneously with either two-color direct excitation of both fluorophores or single-color excitation of the donor fluorophore only. In the latter experiments, the excited-state energy is transferred nonradiatively from a donor to an acceptor fluorophore by FRET (fluorescence resonance energy transfer). The efficiency of...

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“…In addition to the control of 1,4-phenylenedimethanethiol structures on Au(111) imparted by the deposition conditions, we found that chemical doping also resulted in re-arrangment of the molecules. Using a procedure first reported by Labonte et al [5], addition of a strong electron acceptor (in this case, tetracyanoethylene, TCNE) caused the previously upright molecules to adopt a horizontal configuration with respect to the gold surface, as shown in Figure 3A. Figure 3B shows an STM image of the 1,4-phenylenedimethanethiol molecules on Au(111) in this horizontal arrangement.…”

Section: Resultsmentioning

confidence: 86%

Self-Organized Materials: From Organic molecules to Genetically Engineered Gold-Binding Proteins

Zareie¹,

Sarıkaya²,

McDonagh³

et al. 2006

2006 International Conference on Nanoscience and Nanotechnology

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We present examples of ordered assemblies of organic and biological molecules on gold(111) surfaces. The first example shows how control over mono-or multilayer assemblies of 1,4-phenylenedimethanthiol can be achieved and monitored. The second example shows how monolayers on gold can be prepared using amine groups to anchor aromatic molecules to the surface. A third example shows how ordered assemblies of geneticallyengineered inorganic-binding polypeptides can be formed on gold surfaces using a 3-repeat, 14 amino acid gold-binding protein (GBP1).

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Reversibly Altering Electronic Conduction through a Single Molecule by a Chemical Binding Event

Cited by 25 publications

References 32 publications

Electrochemical study of adlayers of α,ω-alkanedithiols on Au(111): Influence of the forming solution, chain length and treatment with mild reducing agents

Electrochemical study of adlayers of α,ω-alkanedithiols on Au(111): Influence of the forming solution, chain length and treatment with mild reducing agents

Individual Molecules of Dye‐Labeled DNA Act as a Reversible Two‐Color Switch upon Application of an Electric Field

Self-Organized Materials: From Organic molecules to Genetically Engineered Gold-Binding Proteins

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