Reversible Posterior Leukoencephalopathy Syndrome

Abe, Kazuo

doi:10.2169/internalmedicine.43.900

Cited by 22 publications

(7 citation statements)

References 13 publications

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“…CNS damage sometimes becomes irreversible even in RPLS if treatment is delayed [15], but our patient was adequately treated soon after admission, and recovered with no neurological sequellae.…”

Section: Discussionmentioning

confidence: 73%

Henoch–Schönlein purpura nephritis complicated by reversible posterior leukoencephalopathy syndrome

et al. 2007

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Section: Discussionmentioning

confidence: 73%

Henoch–Schönlein purpura nephritis complicated by reversible posterior leukoencephalopathy syndrome

et al. 2007

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“…Recurrence is rare, but prolonged seizures, hypertension, or both may result in permanent neurological deficit and cerebral infarction2, 8, 18). If the intervention is not done in a timely manner, the functional vasogenic brain edema may convert to cytotoxic brain edema, giving permanent sequelae15).…”

Section: Discussionmentioning

confidence: 99%

A case of tacrolimus-induced encephalopathy after kidney transplantation

Kim

Son

et al. 2011

Korean J Pediatr

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We present a case of tacrolimus-induced encephalopathy after successful kidney transplantation. An 11-year-old girl presented with sudden onset of neurologic symptoms, hypertension, and psychiatric symptoms, with normal kidney function, after kidney transplantation. The symptoms improved after cessation of tacrolimus. Magnetic resonance imaging (MRI) showed acute infarction of the middle cerebral artery (MCA) territory in the right frontal lobe. Three days later, she had normal mental function and maintained normal blood pressure with left hemiparesis. Follow-up MRI was performed on D19, showing new infarct lesions at both cerebral hemispheres. Ten days later, MRI showed further improvement, but brain single photon emission computed tomography (SPECT) showed mild reduction of uptake in both the anterior cingulate gyrus and the left thalamus. One month after onset of symptoms, angiography showed complete resolution of stenosis. However, presenting as a mild fine motor disability of both hands and mild dysarthria, what had been atrophy at both centrum semiovale at 4 months now showed progression to encephalomalacia. There are two points of interest in this case. First, encephalopathy occurred after administration of tacrolimus and improved after discontinuation of the drug. Second, the development of right-side hemiplegia could not be explained by conventional MRI; but through diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) of white matter tract, visualization was possible.

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“…Some investigators raised possible useful-ness of MRS (Fig. 14) [24,25]. Patients with lymphomatoid granulomatosis showed appearances of lactate peak that may differentiate lymphomatoid granulomatosis from CNS vasculitises scu as SLE and Sjögren's syndrome.…”

Section: Lymphomatoid Granulomatosismentioning

confidence: 99%

“…Wide variety of diseases may develop RPLS and various acute neurological conditions such as stroke, cerebral venous thrombosis, encephalitis, demyelinating disorders, and collagen diseases in the brain should be distinguished from RPLS [25]. Thus, early recognition of this condition is of paramount importance because prompt control of blood pressure or withdrawal of immunosuppressive agents will cause reversal of the syndrome.…”

Section: Reversible Posterior Leukoencephalo-pathy Syndrome (Rpls)mentioning

confidence: 99%

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MRI of Central Nervous System (CNS) Vasculitis

Abe

2006

CMIR

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Vasculitis is inflammation of blood vessel walls, which produces dysfunction in both the peripheral and central nervous system (CNS). In CNS, cerebral ischemia is the major cause for neurological manifestations. Vasculitis affecting the CNS alone is referred to as primary angiitis of the CNS. The pathogenesis of vasculitis includes different immunological mechanisms. Diagnosis of CNS vasculitis depends on a combination of clinical, radiographic and pathologic features, but the gold standard is confirmation of vasculitis in a biopsy specimen. However, before conducting biopsies, imaging study, especially MRI, is essential for diagnosis of CNS vasculitis.In this review, a wide spectrum of MRI features of CNS vasculitis are presented and discussed.

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Reversible Posterior Leukoencephalopathy Syndrome

Cited by 22 publications

References 13 publications

Henoch–Schönlein purpura nephritis complicated by reversible posterior leukoencephalopathy syndrome

Henoch–Schönlein purpura nephritis complicated by reversible posterior leukoencephalopathy syndrome

A case of tacrolimus-induced encephalopathy after kidney transplantation

MRI of Central Nervous System (CNS) Vasculitis

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