Reversible pH‐Dependent Properties of Multilayer Microcapsules Made of Weak Polyelectrolytes

Mauser, Tatjana; Déjugnat, Christophe; Sukhorukov, Gleb B.

doi:10.1002/marc.200400331

Cited by 190 publications

(173 citation statements)

References 44 publications

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“…In literature several papers have been published describing the swelling and dissolution behavior of polyelectrolyte multilayers from weak polyelectrolytes. [26][27][28] The interactions between the successive layers in the (Au NP / PAH) 4 capsules reported in our present paper are also based on the interactions between a weak polyacid, as the Au NP have carboxyl acid groups on their surface, and a weak polybase (i.e., PAH). Therefore, we were interested to know whether our (Au NP /PAH) 4 capsules exhibited a dual responsive behavior both at low and high pH.…”

Section: Resultsmentioning

confidence: 51%

Stimuli‐Responsive Multilayered Hybrid Nanoparticle/Polyelectrolyte Capsules

Geest

Skirtach

Beer

et al. 2007

Macromol. Rapid Commun.

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Gold nanoparticles (AuNP) with carboxyl groups on their surface were used in combination with PAH for the layer‐by‐layer coating of CaCO3 microparticles, followed by the dissolution of the CaCO3 core. SEM, TEM, and confocal microscopy are used to characterize the hybrid nanoparticles/polyelectrolyte capsules. As the AuNP have carboxyl groups on their surface, their charge density is pH dependent; therefore, the capsules exhibit a pH‐dependent swelling and can be deconstructed both at low and high pH. By covalent cross‐linking of the carboxyl groups of the AuNP and the amino groups of the PAH, it is possible to suppress the pH‐responsive behavior. AuNP are used as activation centers using IR light and this ability is used to release encapsulated material from the nanoparticles/polyelectrolyte capsules as well as for the enhancement of detection and imaging of such capsules by Raman microspectrosopy.magnified image

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Section: Resultsmentioning

confidence: 51%

Stimuli‐Responsive Multilayered Hybrid Nanoparticle/Polyelectrolyte Capsules

Geest

Skirtach

Beer

et al. 2007

Macromol. Rapid Commun.

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“…47 The PAH-PSS microcapsules are stable over a wide pH range, whereas microcapsules consisting of PAH and PMAA decompose at pH 2.5 or lower and at pH 11.5 or higher. 48 The pH-dependent permeability and decomposition of LbL microcapsules depends on the acid-base equilibrium of the weak polyelectrolytes in the LbL films. Therefore, the permeability of LbL microcapsules can be manipulated by changing the environmental pH.…”

Section: ·4 Lbl Microcapsulesmentioning

confidence: 99%

Layer-by-layer Thin Films and Microcapsules for Biosensors and Controlled Release

2012

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We present an overview of the preparation and properties of layer-by-layer (LbL) deposited thin films and microcapsules in relation to their use in the development of biosensors and controlled release systems. Enzyme biosensors can be constructed by immobilizing enzymes on the surface of electrodes by LbL deposition without loss of their catalytic activity. In addition to synthetic polymers, binding proteins, such as avidin and lectin, are also used for constructing LbL films through avidin-biotin and lectin-sugar interactions. The performance characteristics of LbL film-based biosensors can be tuned by controlling the number of layers and by the choice of film components. The permeability of polyelectrolyte LbL films to ions and molecules is discussed in relation to the use of the films for eliminating interference in biosensors. The possible use of polysaccharide LbL film-coated electrodes for the construction of biosensors is highlighted, and examples of LbL film-and microcapsule-based optical sensors are described. We then focus on the use of LbL films and microcapsules as vehicles for controlled release, in particular on recent progress in the controlled release of insulin from LbL films and microcapsules. LbL films composed of insulin and polymers are sensitive to environmental pH, and release insulin in response to pH changes, suggesting that insulin LbL films can be used in the development of orally administered insulin. The construction of glucose-dependent insulin release systems using LbL insulin microcapsules functionalized with phenylboronic acid, lectin, and glucose oxidase is also examined.

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“…Therefore, it is necessary to activate its content or release the encapsulated material remotely. Typical release mechanisms are based on a triggered system, such as pH 153,154 laser light, [155][156][157][158] ultrasound, [159][160][161] temperature, 162 or enzymatic degradation. 163 Currently, a variety of the release systems was already realized using gels, 164,165 polymeric micelles, [166][167][168] liposomes, 169,170 colloids, 171 and polyelectrolyte multilayer microcapsules 172 as carriers.…”

Section: Release Of Materialsmentioning

confidence: 99%

“…173 In further studies, they used laser irradiation for the release of dye-labeled dextran inside a living cell, which was encapsulated in poly(styrene sulfonate)/poly(diallyldimethylammonium chloride) microcapsules. 154 Dejugnat and Sukhorukov 153 investigated hollow polyelectrolyte microcapsules consisting of poly(allylamine hydrochloride) and sodium poly(styrene sulfonate), various core templates as manganese and calcium carbonate particles or polystyrene latexes. These polyelectrolyte multilayers respond to a change of pH, leading to a swelling of the capsules in basic conditions, and a shrinking under acidic conditions.…”

Section: Release Of Materialsmentioning

confidence: 99%

From polymeric particles to multifunctional nanocapsules for biomedical applications using the miniemulsion process

Landfester

Musyanovych

Mailänder

2009

J. Polym. Sci. A Polym. Chem.

163

122

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ABSTRACT:The miniemulsions process represents a versatile tool for the formation of polymeric nanoparticles consisting of different kinds of polymer as obtained by a variety of polymerization types ranging from radical, anionic, cationic, enzymatic polymerization to polyaddition, and polycondensation. The process perfectly allows the encapsulation of hydrophilic and hydrophobic liquids and solids in polymeric shells, molecularly dissolved dyes or other components. In combination with a specific functionalization of the nanoparticles' or nanocapsules' surfaces and the possibility to release substances in a defined way from the interior, complex nanoparticles or nanocapsules are obtained, which are ideally suited for application in biomedical application as marker and targeted drug-delivery system. V C 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 2010

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Reversible pH‐Dependent Properties of Multilayer Microcapsules Made of Weak Polyelectrolytes

Cited by 190 publications

References 44 publications

Stimuli‐Responsive Multilayered Hybrid Nanoparticle/Polyelectrolyte Capsules

Stimuli‐Responsive Multilayered Hybrid Nanoparticle/Polyelectrolyte Capsules

Layer-by-layer Thin Films and Microcapsules for Biosensors and Controlled Release

From polymeric particles to multifunctional nanocapsules for biomedical applications using the miniemulsion process

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