Reversible loss of reproductive fitness in zebrafish on chronic alcohol exposure

Dewari, Pooran Singh; Ajani, F.; Kushawah, Gopal; Kumar, Damera Santhosh; Mishra, Rakesh K.

doi:10.1016/j.alcohol.2015.11.006

Cited by 14 publications

(4 citation statements)

References 36 publications

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“…While acute ethanol exposure mildly inhibits shoaling, chronic (8 days) exposure to ethanol surprisingly increases shoal cohesion (Müller et al, 2017b). Chronic ethanol exposure dramatically lowered fertility when at least one of the mating partners was treated, and this inhibition was fully reversed by a 9-week withdrawal program (Dewari et al, 2016).…”

Section: Disease-relevant Social-deficit Models In Zebrafishmentioning

confidence: 99%

The zebrafish subcortical social brain as a model for studying social behavior disorders

Geng

Peterson

2019

Disease Models &Amp; Mechanisms

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Social behaviors are essential for the survival and reproduction of social species. Many, if not most, neuropsychiatric disorders in humans are either associated with underlying social deficits or are accompanied by social dysfunctions. Traditionally, rodent models have been used to model these behavioral impairments. However, rodent assays are often difficult to scale up and adapt to high-throughput formats, which severely limits their use for systems-level science. In recent years, an increasing number of studies have used zebrafish (Danio rerio) as a model system to study social behavior. These studies have demonstrated clear potential in overcoming some of the limitations of rodent models. In this Review, we explore the evolutionary conservation of a subcortical social brain between teleosts and mammals as the biological basis for using zebrafish to model human social behavior disorders, while summarizing relevant experimental tools and assays. We then discuss the recent advances gleaned from zebrafish social behavior assays, the applications of these assays to studying related disorders, and the opportunities and challenges that lie ahead.

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Section: Disease-relevant Social-deficit Models In Zebrafishmentioning

confidence: 99%

The zebrafish subcortical social brain as a model for studying social behavior disorders

Geng

Peterson

2019

Disease Models &Amp; Mechanisms

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“…Studies examining chronic ethanol exposure in zebrafish have reported inconsistent results, possibly due to the many different exposures times, duration of exposure, duration of withdrawal, and concentration of ethanol used (Da Silva Chaves et al, 2018). To date there have been many studies examining the impact of chronic ethanol exposure (Müller et al, 2017; Tran, Chatterjee & Gerlai, 2015; Wong et al, 2010), and yet only a few that have examined withdrawal behaviour (Holcombe et al, 2013; Cachat et al, 2010, Mathur & Guo, 2011; Tran et al, 2016; Pittman & Hylton, 2015; Gerlai et al, 2009; Pittman & Ichikawa, 2013; Müller et al, 2017; Dewari et al, 2016; Benneh et al, 2017). For example, a study by Müller et al (2017) examined the effects of repeated ethanol exposure over the course of 8 days, at 20 min per day, and a dose of 1% v/v.…”

Section: Introductionmentioning

confidence: 99%

Repeated ethanol exposure increases anxiety-like behaviour in zebrafish during withdrawal

Krook

Duperreault

Newton

et al. 2019

PeerJ

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Zebrafish (Danio rerio) are quickly becoming an important model organism in behavioural neuroscience and drug addiction research. Conditioned place preference studies show that drugs of abuse produce responses in zebrafish that are similar to mammalian animal models. Repeated administration of ethanol in zebrafish results in withdrawal-induced behavioural responses that vary with dose and exposure duration, requiring additional investigation. Here, we examine the effects of ethanol withdrawal on anxiety-like behaviours in adult zebrafish after a 21-day ethanol dosing schedule at either 0.4% or 0.8%. Anxiety-like behaviour was measured with the novel object approach test; this test involves placing a fish in a circular arena with a novel object in the centre and observing the amount of exploration of the object. We found increased anxiety-like behaviour during ethanol withdrawal. This study adds to the growing body of literature that validates the zebrafish as a model organism in the field of behavioural neuroscience and addiction.

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“…To date there have been many studies examining the impact of chronic ethanol exposure (e.g. Müller et al, 2017;Tran et al, 2015;Wong et al, 2010), and yet only a few that have examined withdrawal behaviour (Holcombe et al, 2013;Cachat et al, 2010, Mathur & Guo, 2011Tran et al, 2016;Pittman & Hylton, 2015;Gerlai et al, 2009;Pittman & Ichikawa, 2013;Müller et al, 2017;Dewari et al, 2016;Benneh et al, 2017). For example, a study by Müller et al (2017) (Keedwell, Poon, Papadopoulos, Marshall, & Checkley, 2001;Nava et al, 2007), the authors observed a significant elevation in cortisol levels during ethanol withdrawal (Cachat et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Peer Review #3 of "Repeated ethanol exposure increases anxiety-like behaviour in zebrafish during withdrawal (v0.2)"

Silva¹

2019

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Zebrafish (Danio rerio) are quickly becoming an important model organism in behavioural neuroscience and drug addiction research. Conditioned place preference studies show that drugs of abuse produce responses in zebrafish that are similar to mammalian animal models. Repeated administration of ethanol in zebrafish results in varied withdrawalinduced behavioural responses that vary with dose and exposure duration, requiring additional investigation. Here we examine the effects of ethanol withdrawal on anxiety-like behaviours in adult zebrafish after a 21-day ethanol dosing schedule at either 0.4% or 0.8%. Anxiety-like behaviour was measured with the novel object approach test; this test involves placing a fish in a circular arena with a novel object in the center and observing the amount of exploration of the object. We found increased anxiety-like behaviour during ethanol withdrawal. This study adds to the growing body of literature that validates the zebrafish as a model organism in the field of behavioural neuroscience and addiction.

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Reversible loss of reproductive fitness in zebrafish on chronic alcohol exposure

Cited by 14 publications

References 36 publications

The zebrafish subcortical social brain as a model for studying social behavior disorders

The zebrafish subcortical social brain as a model for studying social behavior disorders

Repeated ethanol exposure increases anxiety-like behaviour in zebrafish during withdrawal

Peer Review #3 of "Repeated ethanol exposure increases anxiety-like behaviour in zebrafish during withdrawal (v0.2)"

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