Reversible infertility in a man with 21-hydroxylase deficiency congenital adrenal hyperplasia

Yang, Ronald M.; Fefferman, Richard A.; Shapiro, Charles E.

doi:10.1016/j.fertnstert.2004.08.018

Cited by 17 publications

(5 citation statements)

References 8 publications

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“…In certain cases like our couple, pertinent symptomatology might be mild or absent. Nonspecific features, such as relatively short adult height, relatively small testes, semen disturbances, scrotum hyperpigmentation, hypertrichosis in specific areas such as ears, and occasionally adenomas of testes or adrenals may be the only signs in men (1)(2)(3)6).…”

Section: Discussionmentioning

confidence: 99%

Infertility reversed by glucocorticoids and full-term pregnancy in a couple with previously undiagnosed nonclassic congenital adrenal hyperplasia

Trakakis

Dracopoulou-Vabouli

Dacou-Voutetakis

et al. 2011

Fertility and Sterility

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Section: Discussionmentioning

confidence: 99%

Infertility reversed by glucocorticoids and full-term pregnancy in a couple with previously undiagnosed nonclassic congenital adrenal hyperplasia

Trakakis

Dracopoulou-Vabouli

Dacou-Voutetakis

et al. 2011

Fertility and Sterility

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“…It also has been reported that clomiphene citrate treatment in addition to hormonal manipulation was successful in azoospermic patients with adrenal rests in the testes (7). Therefore, we think that it is important to optimize glucocorticoid replacement therapy to achieve normal sperm function and pregnancy.…”

Section: Discussionmentioning

confidence: 92%

21-Hydroxylase Deficiency Associated with Male Infertility: Report of 2 Cases with Gene Analyses

et al. 2011

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We treated two patients with male infertility due to 21-hydroxylase deficiency. Endocrinologic examinations disclosed low levels of LH and FSH, with elevated ACTH and 17-OH-progesterone in both. In addition, a small testicular tumor was found in Case 1, which disappeared after adrenal replacement. Suppressed gonadotropin levels caused by increased androgen seemed to underlie the sperm dysfunction in these patients. Dexamethasone and then clomiphene were administered in Case 1, and dexamethasone in Case 2. Spermatogenesis was somewhat improved in both patients and pregnancy achieved in Case 2, though spontaneous abortion later occurred.

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“…When it came to attempting pregnancy, just two-thirds of males with congenital adrenal hyperplasia were successful, according to one of these studies [55]. In terms of treatment, a variety of approaches have been examined and found to be effective, including the use of hCG in conjunction with FSH, clomiphene citrate, and intracytoplasmic sperm injection [56,57].…”

Section: Androgen Excessmentioning

confidence: 99%

Endocrinopathies and Male Infertility

Sengupta

Dutta

Karkada

et al. 2021

Life

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Male infertility is approaching a concerning prevalence worldwide, and inflicts various impacts on the affected couple. The hormonal assessment is a vital component of male fertility evaluation as endocrine disorders are markedly reversible causatives of male infertility. Precise hormonal regulations are prerequisites to maintain normal male fertility parameters. The core male reproductive event, spermatogenesis, entails adequate testosterone concentration, which is produced via steroidogenesis in the Leydig cells. Physiological levels of both the gonadotropins are needed to achieve normal testicular functions. The hypothalamus-derived gonadotropin-releasing hormone (GnRH) is considered the supreme inducer of the gonadotropins and thereby the subsequent endocrine reproductive events. This hypothalamic–pituitary–gonadal (HPG) axis may be modulated by the thyroidal or adrenal axis and numerous other reproductive and nonreproductive hormones. Disruption of this fine hormonal balance and their crosstalk leads to a spectrum of endocrinopathies, inducing subfertility or infertility in men. This review article will discuss the most essential endocrinopathies associated with male factor infertility to aid precise understanding of the endocrine disruptions-mediated male infertility to encourage further research to reveal the detailed etiology of male infertility and perhaps to develop more customized therapies for endocrinopathy-induced male infertility.

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Reversible infertility in a man with 21-hydroxylase deficiency congenital adrenal hyperplasia

Cited by 17 publications

References 8 publications

Infertility reversed by glucocorticoids and full-term pregnancy in a couple with previously undiagnosed nonclassic congenital adrenal hyperplasia

Infertility reversed by glucocorticoids and full-term pregnancy in a couple with previously undiagnosed nonclassic congenital adrenal hyperplasia

21-Hydroxylase Deficiency Associated with Male Infertility: Report of 2 Cases with Gene Analyses

Endocrinopathies and Male Infertility

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