The influence of manganese concentration (0.1−20 μM) on the incorporation of [14C] isopentenyl pyrophosphate (IPP) into gibberellin precursors by cell-free extracts from etiolated coleoptiles was investigated in sorghum [Sorghum bicolor (L.) Moench] cultivars ranging in acid-soil stress sensitivity. Mn2+ concentration influenced 14C-IPP incorporation in the acid-soil-sensitive cultivars (Funk G522DR, TAM428, and SC599) but not in acid-soil-stress-tolerant cultivars (SC574, SC283). Mn2+ concentration influenced the conversion of geraniol (G) to farnesol (F) in three cultivars (TAM428, SC283, and SC574). SC574 also exhibited an influence of Mn2+ concentration of F conversion to geranylgeraniol (GG). Mn2+ concentration did not influence the conversion of G to GG in Funk G522DR and F was the major accumulation product. Isoprenoid pathway conversions were not influenced by Mn2+ concentration in SC599 but G accumulated. Thus, there is considerable genetic diversity in the isoprenoid pathway biosynthetic reactions to Mn2+ within a single crop species and changes occur in the production of biosynthetic units as the physiological environment is altered. Acid-soil stress is a multifactored physiological problem to the plant. Explanation of physiological responses to "stress" requires evaluation of individual factors and integration of the whole ecosystem influence on plant growth. Key words: Isoprenoid biosynthesis, manganese concentration, geranyl pyrophosphate, farnesyl pyrophosphate, geranylgeranyl pyrophosphate, acid-soil stress