Reversible effect of MR and ELF magnetic fields (0.5 T and 0.5 mT) on human lymphocyte activation patterns

Salerno, Sergio; Mendola, Carmela La; Casto, Antonio Lo; Mamone, Giuseppe; Caccamo, Nadia; Cardinale, A; Salerno, Alfredo

doi:10.1080/09553000600589131

Cited by 10 publications

(6 citation statements)

References 18 publications

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“…In tumor-bearing mice there was an obviously high proportion of CD4 + T and CD8 + T cells after exposure to MF. However, Salerno et al, [34] found that MF can transiently decrease CD4 + T cell proliferation in vitro . We hypothesized the increasing proportion of CD4 + T cell may be attributed to the recruitment of M1-like macrophage and CD11c + CD40 + DC for CD4 + T cell in vivo, which needs further research to prove.…”

Section: Discussionmentioning

confidence: 98%

Low Frequency Magnetic Fields Enhance Antitumor Immune Response against Mouse H22 Hepatocellular Carcinoma

et al. 2013

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ObjectiveMany studies have shown that magnetic fields (MF) inhibit tumor growth and influence the function of immune system. However, the effect of MF on mechanism of immunological function in tumor-bearing mice is still unclear.MethodsIn this study, tumor-bearing mice were prepared by subcutaneously inoculating Balb/c mice with hepatocarcinoma cell line H22. The mice were then exposed to a low frequency MF (0.4 T, 7.5 Hz) for 30 days. Survival rate, tumor growth and the innate and adaptive immune parameters were measured.ResultsMF treatment could prolong survival time (n = 28, p<0.05) and inhibit tumor growth (n = 9, p<0.01) in tumor-bearing mice. Moreover, this MF suppressed tumor-induced production of cytokines including interleukin-6 (IL-6), granulocyte colony- stimulating factor (G-CSF) and keratinocyte-derived chemokine (KC) (n = 9–10, p<0.05 or 0.01). Furthermore, MF exposure was associated with activation of macrophages and dendritic cells, enhanced profiles of CD4+ T and CD8+ T lymphocytes, the balance of Th17/Treg and reduced inhibitory function of Treg cells (n = 9–10, p<0.05 or 0.01) in the mice model.ConclusionThe inhibitory effect of MF on tumor growth was related to the improvement of immune function in the tumor-bearing mice.

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Section: Discussionmentioning

confidence: 98%

Low Frequency Magnetic Fields Enhance Antitumor Immune Response against Mouse H22 Hepatocellular Carcinoma

et al. 2013

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“…The exposure to 2, 5, or 14 T SMFs for 24 h caused a statistically significant enhancement in somatic recombination frequency in the postreplication repair-deficient Drosophila melanogaster. Salerno et al [2006] investigated the release of cytokines, expression of surface markers, cell proliferation and levels of cytosolic free calcium in human CD4…”

Section: Introductionmentioning

confidence: 99%

Effects of homogeneous and inhomogeneous static magnetic fields combined with gamma radiation on DNA and DNA repair

Kubinyi

Zeitler

Thuróczy

et al. 2010

Bioelectromagnetics

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The aim of this study was to reveal whether static magnetic fields (SMFs) influence the repair of radiation-damaged DNA on leukocytes or has any effect on DNA. After 4 Gy of (60)Co-gamma irradiation, some of the samples were exposed to inhomogeneous SMFs with a lateral magnetic flux density gradient of 47.7, 1.2, or 0.3 T/m by 10 mm lateral periodicity, while other samples were exposed to homogeneous SMF of 159.2 +/- 13.4 mT magnetic flux density for a time period of 0.5 min, 1, 2, 4, 6, 18, 20, or 24 h. Another set of samples was exposed to the aforementioned SMFs before gamma irradiation. The following three groups were examined: (i) exposed to SMF only, (ii) exposed to SMF following irradiation by (60)Co-gamma, and (iii) exposed to SMF before (60)Co-gamma irradiation. The analysis of the DNA damage was made by single-cell gel electrophoresis technique (comet assay). Statistically significant differences were found at 1 h (iSMF), 4 h (hSMF), and 18 h (hSMF) if samples were exposed to only SMF, compared to control. When the SMF exposure followed the (60)Co-gamma irradiation, statistically significant differences were found at 1 h (iSMF) and 4 h (hSMF). If exposure to SMF preceded (60)Co-gamma irradiation, no statistically significant difference was found compared to 4 Gy gamma-irradiated group.

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“…Up-regulating immune functions might need time and dose-control of the magnetic field. Transient biological effect on T lymphocytes were induced by SMF (0.5 T) [10], while long-term (30 days) exposure in SMF ( to T) showed no change in the total leukocytes count [11]. So further researches are required to make sure the base line of the exposure dose and clarify its mechanisms.…”

Section: Discussionmentioning

confidence: 97%

Inhibitory Effects of Moderate Static Magnetic Field on Leukemia

Yang

Wang

et al. 2009

IEEE Trans. Magn.

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The purpose of this study is to investigate the effects of moderate static magnetic field (SMF, 0.2-0.4 T) on experimental murine leukemia and its possible mechanism. As in vivo and in vitro models, normal mice, mice bearing L1210 tumor and L1210 cell line were exposed to moderate SMF, respectively. The results showed that the average lifetime of mice bearing L1210 was prolonged to 12 days by SMF, but just 6 days in the unexposure group. After being exposed to SMF for 10 days, the spleen and thymus index of normal mice increased. The L1210 cell proliferation was suppressed by SMF within the first 3 days but enhanced in the following 2 days. These results suggested that the regulating effects of SMF on immune functions may have potential contribution to tumor therapy.

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Reversible effect of MR and ELF magnetic fields (0.5 T and 0.5 mT) on human lymphocyte activation patterns

Abstract: These results indicate that static magnetic fields (SMF) can give rise to transient biological effects on T lymphocytes and the present system is a sensitive model for understanding the effects of MF on the immune system.

Cited by 10 publications

References 18 publications

Low Frequency Magnetic Fields Enhance Antitumor Immune Response against Mouse H22 Hepatocellular Carcinoma

Low Frequency Magnetic Fields Enhance Antitumor Immune Response against Mouse H22 Hepatocellular Carcinoma

Effects of homogeneous and inhomogeneous static magnetic fields combined with gamma radiation on DNA and DNA repair

Inhibitory Effects of Moderate Static Magnetic Field on Leukemia

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