Reversible Effect of Magnetic Fields on Human Lymphocyte Activation Patterns: Different Sensitivity of Naive and Memory Lymphocyte Subsets

Salerno, Sergio; Mendola, Carmela La; Manna, Marco Pio La; Casto, Antonio Lo; Caccamo, Nadia; Salerno, Alfredo

doi:10.1667/rr1761.1

Cited by 8 publications

(12 citation statements)

References 18 publications

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“…A number of studies have reported before that ELF electromagnetic fields can elicit proliferative responses in various cell types (57-61), whereas others have described no field effects or even antiproliferative responses in different biosystems (62)(63)(64)(65). These results are not necessarily contradictory.…”

Section: Discussionmentioning

confidence: 99%

Influence of a 50 Hz magnetic field and of all-trans‑retinol on the proliferation of human cancer cell lines

Trillo

2012

Int J Oncol

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Abstract. In vitro exposure to power frequency magnetic fields (MF) has been reported to influence cell proliferation and differentiation. However, the nature of the response of different human cancer cell types to these fields has not been sufficiently characterized. The present work investigates the response of two proliferating human cell lines of neuroblastoma (NB69) and hepatocarcinoma (HepG2) to a 42 h, intermittent treatment with a weak, 100 µT, 50 Hz MF, alone or in combination with 0.5 µM all-trans-retinol (ROL), a retinoid currently applied in oncostatic therapies. In each experimental replicate the cell samples were submitted to one of the following treatment combinations: MF+/ROL+, MF+/ ROL-, MF-/ROL+ or MF-/ROL-. The proliferative response was determined by cell counting (Trypan blue exclusion), BrdU incorporation and by spectrophotometric analysis of total protein and DNA content. The results show that when administered separately, the two treatments, MF and ROL, significantly enhanced cell proliferation in both cell lines. In NB69 simultaneous administration of MF and ROL induced an additive effect on cell proliferation, associated to increased DNA content. By contrast, in HepG2 the ROL-induced cell proliferation and increased protein content were partially blocked by simultaneous exposure to MF. Taken together, these data show that both agents, a weak MF and ROL at a low concentration, induce proliferative responses in the two assayed human cell lines. However, significant differences were observed between the responses of the two cellular species to the combined treatment with ROL and MF, indicating that the mechanisms underlying the cellular response to each of the two agents can mutually interact in a manner that is cell type-specific.

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Section: Discussionmentioning

confidence: 99%

Influence of a 50 Hz magnetic field and of all-trans‑retinol on the proliferation of human cancer cell lines

Trillo

2012

Int J Oncol

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“…Not only because several cytokines, such as pro-inflammatory cytokines: IL-6 [28][29][30][31][32][33], IL-8 [29,31,34], tumor necrosis factor-α (TNF-α) [29,32,33,35], and anti-inflammatory cytokine IL-10 [29,32,35], were shown to have a significant contribution to either the development or the evolution of pathological conditions such as EAE or MS, but the release of these cytokines was also investigated under SMF-exposure. It is conceivable that the self-motion of animals in a whole-body SMF may generate currents especially, when animals are free to move as discussed to some details in [25,26,36].…”

Section: Discussionmentioning

confidence: 99%

The effect of whole-body, repetitive, inhomogeneous static magnetic field-exposure on the symptoms of experimental autoimmune encephalomyelitis in mice

László

Solténszky

Pórszász

et al. 2014

Journal of Complementary and Integrative Medicine

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Experimental autoimmune encephalomyelitis (EAE) is a model for human multiple sclerosis (MS) in rodents. Static magnetic field (SMF)-exposure was shown to be beneficial in specific cases of inflammatory background, where it suppresses symptoms. The null-hypothesis was that animals with induced EAE exposed to SMF would show different seriousness of symptoms, than those in the sham-exposed control group. Three replicated series of repetitive, 30 min/day whole-body exposure to SMF with 477 mT peak-to-peak magnetic induction and 48 T/m lateral induction gradient was tested on female CSJLF1 mice with a mild, mouse spinal cord homogenate emulsion-induced EAE. Conventional scores of the animal response to EAE were compared between sham- and SMF-exposed groups of animals. Following pilot test we used 18 animals per group. Primary outcome measure was the daily group average of standard EAE scores. Results show that SMF-exposure has a strong, reproducible, and significantly beneficial effect up to 51.82% (p<0.001) over sham-exposure on the symptoms of EAE in the course of the 25 days of the experiment. This study aimed to build experimental research foundation for a later therapy option by applying SMF-exposure in the clinical management of MS.

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“…The most common/known biological problem during MR is that of heating, due to RF fields [17]. This heating of tissues is maximum at the surface and minimal at the centre of the body.…”

Section: Biological Effects Of Non-ionizing Electromagnetic Fields Emmentioning

confidence: 99%

“…Usually, there are no problems in adults, who dissipate heat mainly with peripheral vasodilatation. Infants and newborns, particularly if preterm, have immature thermoregulation [17,18]. The RF power absorbed per unit of mass of an object is defined Specific Absorption Rate (SAR) and is measured in watts per kilogram (W kg −1 ).…”

Section: Biological Effects Of Non-ionizing Electromagnetic Fields Emmentioning

confidence: 99%

“…Usually, they have supplementary equipment, such as monitoring, ventilation and infusion pumps. As synthesized by Arthur [17]: proper requirements must be accessible when sick young children are in the MR environment: MR-compatible fibre-optic temperature monitoring, pulse oximeter, ECG leads. Standard equipments such as laryngoscope blades, handles and stethoscopes are usually not MR compatible.…”

Section: Risks From Ferromagnetic External Objects and Implanted Devicesmentioning

confidence: 99%

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Is MRI imaging in pediatric age totally safe? A critical reprisal

et al. 2018

Self Cite

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Current radiological literature is strongly focussed on radiation imaging risks. Indeed, given there is a small but actual augment in cancer risk from exposure to ionizing radiation in children, it is important to understand what the risk of alternative techniques could be. We retrospectively review literature data concerning possible MR imaging risks, focussing on the biological effects of MR, sedation and gadolinium compound risks when dealing with infant patients. The main concerns can be summarized in: (1) Biological effects of non-ionizing electromagnetic fields (EMF) employed-whose mechanisms of interaction with human tissues are polarization, induced current, and thermal heating, respectively. (2) Risks associated with noises produced during MRI examinations. (3) Hazards from ferromagnetic external and/or implanted devices-whose risk of being unintentionally brought inside MR room is higher in children than in adults. (4) Risks associated with sedation or general anaesthesia, essential problem in performing MR in very young patients, due to the exam long-lasting. (5) Risks related to gadolinium-based contrast agents, especially considering the newly reported brain deposition.

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Reversible Effect of Magnetic Fields on Human Lymphocyte Activation Patterns: Different Sensitivity of Naive and Memory Lymphocyte Subsets

Cited by 8 publications

References 18 publications

Influence of a 50 Hz magnetic field and of all-trans‑retinol on the proliferation of human cancer cell lines

Influence of a 50 Hz magnetic field and of all-trans‑retinol on the proliferation of human cancer cell lines

The effect of whole-body, repetitive, inhomogeneous static magnetic field-exposure on the symptoms of experimental autoimmune encephalomyelitis in mice

Is MRI imaging in pediatric age totally safe? A critical reprisal

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