Reversible Corpus callosum Lesions in a Patient with Marchiafava-Bignami Disease: Serial Changes on MRI

A patient with Marchiafava–Bignami disease as a complication of diabetes mellitus treated effectively with cortico steroid

“…11,12 High signal intensity on DWI occurs due to reduced diffusion capacity of the surrounding tissue, as caused by swollen myelin sheaths, 13 which suggests a reversible lesion. 14,15 There are some reports that such lesions can be effectively treated with steroids. 9,16,17 Tao et al reported a 16-year-old, female patient with anorexia nervosa and MBD who showed a complete response when treated with methylprednisolone (1000 mg/day for three days).…”

Alcohol-induced changes in the brain as assessed by MRI and CT

“…In the chronic phase, MBD lesions will eventually become cystic and well marginated. Occasionally they may be reversible [44].…”

Ethanol

“…740,743,744 One reported patient had Balint syndrome. [749][750][751][752][753][754][755] Histological changes resemble those of central pontine myelinolysis but are located, with sharp demarcation, in the medial zone of the corpus callosum, sparing the dorsal and ventral rims and spreading rostrocaudally. A patient with apraxia, grasp reflexes, and gait ataxia improved spontaneously; following his death 3 years later from liver failure, autopsy revealed Marchiafava-Bignami disease.…”