“…In contrast, very limited catalytic systems were found to selectively prepare the 1,3,5-substitution pattern of poly-substituted benzenes, which feature geometric symmetry and electronic uniformity and could have intriguing applications in materials science and biochemistry. 10 The synthesis of 1,3,5-substituted benzenes usually involves expensive reagents, elaborately designed ligands or structurally complicated complexes, as shown in the cases of mononuclear titanium, 11 iron 12 and indium 13 complexes, dinuclear chromium 14 and niobium 15 catalysts and polymer-supported cobalt 16 catalysts (Scheme 1A (b)). A very recent publication 17 reported the Ni(II)-B(OH) 2 co-catalyzed cycloaddition reaction of terminal alkynes for the highly regioselective synthesis of 1,3,5-substitution products at a relatively high temperature (Scheme 1A (c)).…”