Reversible Cerebral Vasoconstriction Syndrome

Sorensen, Derek

doi:10.1001/jamaneurol.2015.3472

Cited by 11 publications

(6 citation statements)

References 3 publications

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“…In both syndromes, a blood flow dysregulation has been suggested to have a causative role but other mechanisms as immune system dysregulation or endothelium dysfunction may play a role in pathogenesis or in clinical course (1,5). However, the occurrence of both syndromes in the same patients (6-10) makes conceivable a common origin or a common pathophysiological pattern making differential diagnosis difficult (11,12), even if a possible overlap syndrome could not be completely ruled out (13).…”

Section: Pathophysiological Basismentioning

confidence: 99%

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Posterior Reversible Encephalopathy Syndrome and Reversible Cerebral Vasoconstriction Syndrome: Clinical and Radiological Considerations

2020

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Posterior reversible encephalopathy syndrome (PRES) and reversible cerebral vasoconstriction syndrome (RCVS) are relatively uncommon neurological disorders, but their detection has been increasing mainly due to clinical awareness and spreading of magnetic resonance imaging (MRI). Because these syndromes share some common clinical and radiologic features and occasionally occur in the same patient, misdiagnosis may occur. PRES is characterized by varied neurological symptoms including headache, impaired visual acuity or visual field deficit, confusion, disorders of consciousness, seizures, and motor deficits often associated to peculiar neuroradiological pattern even if uncommon localization and ischemic or hemorrhagic lesions were described. RCVS is a group of diseases typically associated with severe headaches and reversible segmental vasoconstriction of cerebral arteries, often complicated by ischemic or hemorrhagic stroke. Pathophysiological basis of PRES and RCVS are still debated but, because they share some risk factors and clinical features, a possible common origin has been supposed. Clinical course is usually self-limiting, but prognosis may fluctuate from complete recovery to death due to complications of ischemic stroke or intracranial hemorrhage. Neuroradiological techniques such as digital angiography and MRI are helpful in the diagnostic pathway and a possible prognostic role of MRI has been suggested. This review will serve to summarize clinical, neuroradiological features and controversies underlying both syndromes that may mislead the diagnostic pathway and their possible relationship with pathophysiology, clinical course, and prognosis.

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Section: Pathophysiological Basismentioning

confidence: 99%

“…Common features observed in PRES and RCVS make conceivable a shared pathophysiological pathway or common effects on the intracranial vascularization (12).…”

Section: Role Of Neuroimaging In Understanding Pathophysiologymentioning

confidence: 99%

Posterior Reversible Encephalopathy Syndrome and Reversible Cerebral Vasoconstriction Syndrome: Clinical and Radiological Considerations

2020

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“…A rare neurovascular disorder, RCVS is characterized by diffuse vasospasm of the cerebral arterial system, preceded by thunderclap headaches with or without other neurologic symptoms. 6,7 Evidence suggesting systemic vascular involvement in RCVS is sparse.…”

Section: Discussionmentioning

confidence: 99%

“…11 According to available data, calcium channel blockers are the therapeutic mainstay in RCVS. [5][6][7][8] After the diagnosis of RCVS, our patient was switched from propranolol to a calcium channel blocker (diltiazem) to treat the coronary and cerebral arterial vasospasms. Her symptoms completely resolved, and she was doing well on follow-up visits.…”

Section: Discussionmentioning

confidence: 99%

Reversible Cerebral Vasoconstriction Syndrome Associated with Coronary Artery Vasospasm

Laeeq¹,

Berman²,

Khalid³

et al. 2019

Texas Heart Institute Journal

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Reversible cerebral vasoconstriction syndrome is a rare disorder associated with neurologic symptoms secondary to diffuse cerebral vasospasm. Cardiac involvement in this disease is exceedingly rare. A 50-year-old woman was admitted to our hospital for evaluation of chest pain. During a 3-year period, she had been admitted multiple times because of chest pain and elevated serum cardiac enzymes. Transthoracic echocardiograms showed transient wall-motion abnormalities; however, coronary angiograms revealed no coronary artery disease. At the current admission, she had a thunderclap headache, and cerebral angiograms revealed diffuse cerebral vasoconstriction that improved after verapamil infusion, confirming the diagnosis of reversible cerebral vasoconstriction syndrome. The patient was treated successfully with oral diltiazem and had no recurrence of symptoms. We describe what we think is the first reported case of coronary artery spasm in association with reversible cerebral vasoconstriction syndrome. Future research should be focused on identifying treatment options and defining the mechanisms by which the cerebral and coronary vasculature are affected.

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“…1 Reversible cerebral vasoconstriction syndrome presents with thunderclap headache and represents a group of conditions that show reversible multifocal narrowing of cerebral arteries. 2 We present a case of a 48-year-old women who presented with severe headache after device closure of a ventricular septal defect. For this patient, we diagnosed reversible cerebral vasoconstriction syndrome that improved on follow-up angiography.…”

mentioning

confidence: 99%

Severe headache in a middle-aged woman after device closure of a ventricular septal defect

Lee

Song

2022

Cardiol Young

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Reversible cerebral vasoconstriction syndrome presents with thunderclap headache and represents a group of conditions that show reversible multifocal narrowing of cerebral arteries. Some patients who undergo device closure of an atrial septal defect complain of headache, which are posited as a migraine. Here we report a case of severe headache due not to migraine but reversible cerebral vasoconstriction syndrome after device closure of a ventricular septal defect.

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Reversible Cerebral Vasoconstriction Syndrome

Cited by 11 publications

References 3 publications

Posterior Reversible Encephalopathy Syndrome and Reversible Cerebral Vasoconstriction Syndrome: Clinical and Radiological Considerations

Posterior Reversible Encephalopathy Syndrome and Reversible Cerebral Vasoconstriction Syndrome: Clinical and Radiological Considerations

Reversible Cerebral Vasoconstriction Syndrome Associated with Coronary Artery Vasospasm

Severe headache in a middle-aged woman after device closure of a ventricular septal defect

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