Reversible Cardiac Dysfunction Associated with Interferon Alfa Therapy in AIDS Patients with Kaposi's Sarcoma

Lr, Deyton; Walker, Ruth; Kovacs, Joseph A.; Herpin, Betsey; Parker, M.; Masur, Henry; As, Fauci; Hc, Lane

doi:10.1056/nejm198911023211806

Cited by 119 publications

(32 citation statements)

References 13 publications

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“…Similarly, during antitumour therapy with cytokines (Deyton et al, 1989;Nora et al, 1989) or after exposure to cytokines in vitro (Hosenpud et al, 1989;Hollenberg et al, 1989;Sobotka et al, 1990;Wiechmann et al, 1991), a profound depression in cardiac function has been observed. Moreover, IL-I and TNF have been shown to diminish the P-adrenoceptor-mediated increase in contractility in cultured cardiac myocytes (Gulick et al, 1989).…”

Section: No Synthase Infreshly Isolated Cardiac Myocytesmentioning

confidence: 98%

“…Our finding that endotoxin induces the myocardium to synthesize NO by a Ca2"-independent enzyme is likely to have major consequences in our understanding of the cardiomyopathies associated with septic shock, inflammatory diseases of the heart such as endocarditis and myocarditis, idiopathic dilated cardiomyopathy, allograft rejection, burn trauma and anti-tumour therapy with cytokines (Deyton et al, 1989). As endotoxin, exotoxin and infection with parasites have cardiac depressant effects similar to those seen in sepsis (Cunnion & Parillo, 1989) it may be that NO represents the final common pathway of disparate immunological challenges resulting in the pathophysiological alterations seen in these disorders.…”

Section: No Synthase Infreshly Isolated Cardiac Myocytesmentioning

confidence: 99%

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Induction and potential biological relevance of a Ca²⁺‐independent nitric oxide synthase in the myocardium

Schulz

Nava

Moncada

1992

British J Pharmacology

592

217

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We have investigated whether the myocardium and isolated cardiac myocytes can express a Ca2+‐independent NO synthase after treatment with endotoxin or cytokines. Nitric oxide synthesis was measured in cytosols from the left ventricular wall from rats treated with endotoxin, or from freshly isolated myocytes from adult rats treated in vitro with cytokines. Cytosols from the ventricle of saline‐treated control animals showed only Ca2+‐dependent NO synthesis. After treatment with endotoxin, the expression of an inducible, Ca2+‐independent NO synthase was observed. The activity of this enzyme was maximal at 6 h and returned towards control levels by 18 h; no alterations occurred in the Ca2+‐dependent NO synthase activity. Parallel to this enzyme induction there was an increase in myocardial guanosine 3′:5′‐cyclic monophosphate (cyclic GMP) and plasma nitrite and nitrate (NO−x). All these changes were prevented by pretreatment of the rats with dexamethasone. Myocytes possessed Ca2+‐dependent NO synthase activity and expressed, after treatment with tumour necrosis factor‐α (TNF‐α) and interleukin‐1β (IL‐1β), a Ca2+‐independent NO synthase, the induction of which was prevented by dexamethasone and cycloheximide. Since increases in cyclic GMP levels in the heart are associated with reduced myocardial contractility, it is possible that the enhanced production of NO by a Ca2+‐independent enzyme accounts, at least in part, for the depression of myocardial contractility seen in septic shock, cardiomyopathies, allograft rejection, burn trauma, as well as during anti‐tumour therapy with cytokines.

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Section: No Synthase Infreshly Isolated Cardiac Myocytesmentioning

confidence: 98%

Section: No Synthase Infreshly Isolated Cardiac Myocytesmentioning

confidence: 99%

Induction and potential biological relevance of a Ca²⁺‐independent nitric oxide synthase in the myocardium

Schulz

Nava

Moncada

1992

British J Pharmacology

592

217

View full text Add to dashboard Cite

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“…Pharmacotherapy is also potentially associated with LV dysfunction in AIDS patients. Therapeutic agents implicated as potential cardiac toxins include zidovudine [Herskowitz et al, 1992b;d'Amati et al, 1992], and interferon alfa-2 [Deyton et al, 1989;Zimmerman et al, 1994]. If neoplastic infiltration is suspected as a cause of LV dysfunction, cardiac computed tomography or magnetic resonance imaging may be a useful adjunct to echocardiography for characterizing cardiac involvement.…”

Section: Differential Diagnosis Of Myocarditis In Hivmentioning

confidence: 99%

Myocarditis in HIV Positive Patients

Cambrea¹

2011

Myocarditis

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“…In many older patients, it is not only the existence of poor prognostic factors for antiviral treatment, but also concurrent diseases of the heart, kidney, lung and arterial vessels that render IFN therapy difficult (32).…”

Section: Concurrent Conditionsmentioning

confidence: 99%

Patients with Chronic Hepatitis C - Who Should Not Be Treated?

Schüler

Manns

2000

Canadian Journal of Gastroenterology

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The decision to treat a patient with chronic hepatitis C (CHC) is based on what is known about the risk factors for developing liver cirrhosis or hepatocellular carcinoma, as well as on conditions that contraindicate therapy or impair therapy effectiveness. Several factors, including age, treatment side effects, disease severity, concurrent diseases and life conditions, may render treatment decisions more difficult. This review focuses on identifying CHC patients who should not receive treatment.

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Reversible Cardiac Dysfunction Associated with Interferon Alfa Therapy in AIDS Patients with Kaposi's Sarcoma

Cited by 119 publications

References 13 publications

Induction and potential biological relevance of a Ca²⁺‐independent nitric oxide synthase in the myocardium

Induction and potential biological relevance of a Ca²⁺‐independent nitric oxide synthase in the myocardium

Myocarditis in HIV Positive Patients

Patients with Chronic Hepatitis C - Who Should Not Be Treated?

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Reversible Cardiac Dysfunction Associated with Interferon Alfa Therapy in AIDS Patients with Kaposi's Sarcoma

Cited by 119 publications

References 13 publications

Induction and potential biological relevance of a Ca2+‐independent nitric oxide synthase in the myocardium

Induction and potential biological relevance of a Ca2+‐independent nitric oxide synthase in the myocardium

Myocarditis in HIV Positive Patients

Patients with Chronic Hepatitis C - Who Should Not Be Treated?

Contact Info

Product

Resources

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Induction and potential biological relevance of a Ca²⁺‐independent nitric oxide synthase in the myocardium

Induction and potential biological relevance of a Ca²⁺‐independent nitric oxide synthase in the myocardium