Reversible bone marrow necrosis after all-trans retinoic acid induction therapy for acute promyelocytic leukaemia

Rapid resolution of bone marrow necrosis mimicking relapse of pediatric acute lymphoblastic leukemia

“…The most common etiology of BM necrosis is the underlying malignant disease, particularly hematologic malignancies [ 3 , 4 ]. Rarely, it may be caused by chemotherapy such as imatinib, all-trans-retinoic acid (ATRA), or arsenic trioxide, as well as immunotherapeutic agents [ 5 - 9 ]. In addition, granulocyte-colony stimulating factor (G-CSF), administered after chemotherapy to aid hematologic recovery, has been associated with the development of BM necrosis [ 10 ].…”