Reversible blindness after erroneous prescription of closantel: A case report

Abstract

This is an open access article under the terms of the Creat ive Commo ns Attri butio n-NonCo mmerc ial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

Closantel toxicity

“…In Lithuania, in 1993, donated closantel was mistakenly given to 11 women to treat endometritis 14 15. A summary of those cases of closantel poisoning in humans previously described is given in table 1 3 8 9 15–21…”

“…Optic nerve involvement ranging from blurring of the optic disc margins and unilateral or bilateral optic disc oedema in the acute stage to optic disc atrophy later has been described 3 9 16 18 19 21. Outer retinal layer thinning with spicule-like hyperpigmentation owing to the involvement of photoreceptor and retinal pigment epithelium layers15 may well be a relatively late finding.…”

“…As the drug binds to plasma albumin, plasmapheresis has been used in the management of three previously reported cases of human ingestion of this drug 8 20 21. Its utility in this regard may be greatest in those patients who present early following drug ingestion—those patients presenting 3 and 4 days after having taken closantel8 21 recovered and had better vision than those patients presenting 7 days after having done the same 20. Interestingly, none of these reports8 20 21 detail the amount of closantel removed by plasmapheresis.…”

“…Its utility in this regard may be greatest in those patients who present early following drug ingestion—those patients presenting 3 and 4 days after having taken closantel8 21 recovered and had better vision than those patients presenting 7 days after having done the same 20. Interestingly, none of these reports8 20 21 detail the amount of closantel removed by plasmapheresis.…”

Dosis, excesos y reacciones adversas del closantel en ovinos y caprinos en México

“…(1 a 3 días post-ingesta) con plasmaféresis y metilprednisona mejoraron la visión a mediano plazo (18 meses de seguimiento) (Cheraghmakani et al 2021;Khalili y Zareei 2021).…”