Reversible Azoospermia Induced by the Anabolic Steroid 19-Nortestosterone

Schürmeyer, T. H.; Belkien, L.; Knuth, Ulrich A.; Nieschlag, Eberhard

doi:10.1016/s0140-6736(84)91752-5

Cited by 92 publications

(18 citation statements)

References 15 publications

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“…For these reasons, it is important not to overstate the dangers of AAS use 41 42. Adverse effects are dose-related and largely reversible following cessation of use 43 44. This supports the finding by Amory et al 13 that serum testosterone did not differ significantly between treated and placebo limbs at five weeks post-TKR.…”

Section: Discussionsupporting

confidence: 78%

Anabolic steroids in patients undergoing total knee arthroplasty

et al. 2012

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ObjectivesTo systematically review the evidence for using anabolic-androgenic steroids (AAS) to aid rehabilitation following total knee replacement (TKR).DesignSystematic review of all clinical study designs.Data sourcesMEDLINE, EMBASE, AMED, CINAHL and the Cochrane Library were searched from inception to August 2012.Eligibility criteriaAll clinical study designs without language or patient demographic limits.Outcome measuresAll functional, physiological and administrative outcomes as well as reporting of adverse events.ResultsOnly two small randomised controlled trials satisfied the inclusion criteria. Statistically significant improvements were reported in the AAS group for quadriceps strength at 3 (p=0.02), 6 (p=0.01) and 12 (p=0.02) months, Functional Independence Measure score at 35 days (p=<0.05) and Knee Society Score at 6 weeks (p=0.02), 6 months (p=0.04) and 12 months (p=0.03). However, differences in hamstring strength, bone mineral density, sit-to-stand testing, walking speed, length of hospital stay and need for further inpatient rehabilitation did not reach statistical significance. There were no reported adverse events.ConclusionsThere is insufficient evidence to recommend routine administration of AAS to patients undergoing TKR. However, pilot data suggest that AAS can be administered safely and may improve important postoperative outcome measures. This justifies a randomised trial sufficiently powered to identify between-group differences likely to be of clinical significance.

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Section: Discussionsupporting

confidence: 78%

Anabolic steroids in patients undergoing total knee arthroplasty

et al. 2012

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“…All drugs containing male hormones or their derivatives have the potential to impair sperm proliferation and/or maturation, suppress spermatogenesis, and inhibit the testicular function, potentially leading to oligozoospermia. There is extensive evidence for the negative clinical impact of hormones on the fertility of healthy men (see [49, 51, 52, 54, 57, 62, 64, 67–69] for examples), supporting the warnings included in the drug labels. Therefore, patients being prescribed any type of male hormone or derivative should be counseled that these agents may decrease their fertility.…”

Section: The Drugs Most Likely To Affect Human Sperm Production and Mmentioning

confidence: 99%

FDA-approved medications that impair human spermatogenesis

et al. 2016

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We herein provide an overview of the single-ingredient U.S. Food and Drug Administration (FDA)-approved drugs that affect human spermatogenesis, potentially resulting in a negative impact on male fertility. To provide this information, we performed an in-depth search of DailyMed, the official website for FDA-approved drug labels. Not surprisingly, hormone-based agents were found to be the drugs most likely to affect human spermatogenesis. The next category of drugs most likely to have effects on spermatogenesis was the antineoplastic agents. Interestingly, the DailyMed labels indicated that several anti-inflammatory drugs affect spermatogenesis, which is not supported by the peer-reviewed literature. Overall, there were a total of 65 labels for drugs of various classes that showed that they have the potential to affect human sperm production and maturation. We identified several drugs indicated to be spermatotoxic in the drug labels that were not reported in the peer-reviewed literature. However, the details about the effects of these drugs on human spermatogenesis are largely lacking, the mechanisms are often unknown, and the clinical impact of many of the findings is currently unclear. Therefore, additional work is needed at both the basic research level and during clinical trials and post-marketing surveillance to fill the gaps in the current knowledge. The present findings will be of interest to physicians and pharmacists, researchers, and those involved in drug development and health care policy.

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“…Data from the development of androgenic steroids for male contraception indicate that reversal of effects can take up to 12 months after stopping the drugs 2. Case reports indicate that problems may persist for up to three years 6 7.…”

Section: Commentmentioning

confidence: 99%

“…Among other side effects androgenic steroids induce hypogonadotrophic hypogonadism with subsequent azoospermia 2. Over the past year we have noted an increased number of men attending the infertility clinic who have been using anabolic steroids for body building.…”

mentioning

confidence: 99%