1999
DOI: 10.1159/000018297
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Reversible Ascending Motor Neuropathy as a Side Effect of Systemic Treatment with Ciclosporine for Nodular Prurigo

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Cited by 11 publications
(5 citation statements)
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References 13 publications
(10 reference statements)
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“…3 Treatment with cyclosporine has been associated with adverse events, including creatinine elevation, hypertension, gastric upset, muscle pains, angioedema, gingival hyperplasia, and neuropathy. 4 Siepmann et al published a report on a series of 14 patients treated with cyclosporine showing a significant response in 13 patients, 7 of whom experienced the aforementioned side effects. 5 We present a retrospective chart review of PN patients seen in the academic medical centerebased practices of 2 physicians (Drs Orlow and Cohen) from 2005-2015 that illustrates the rapid improvement cyclosporine can afford patients with PN.…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…3 Treatment with cyclosporine has been associated with adverse events, including creatinine elevation, hypertension, gastric upset, muscle pains, angioedema, gingival hyperplasia, and neuropathy. 4 Siepmann et al published a report on a series of 14 patients treated with cyclosporine showing a significant response in 13 patients, 7 of whom experienced the aforementioned side effects. 5 We present a retrospective chart review of PN patients seen in the academic medical centerebased practices of 2 physicians (Drs Orlow and Cohen) from 2005-2015 that illustrates the rapid improvement cyclosporine can afford patients with PN.…”
mentioning
confidence: 99%
“…To the Editor: The efficacy and safety of omalizumab for the adjunctive treatment of chronic spontaneous urticaria (CSU) is well documented. [1][2][3][4] However, many patients experience disease flare-ups at variable intervals after their last omalizumab dose, and…”
mentioning
confidence: 99%
“…Auch milde (Leuko-)Enzephalopathien mit Verwirrtheit und Desorientiertheit (bis 30 % aller Behandelten) [82], Lethargie [22], aber auch schwerere Leukoenzephalopathien [91][92][93] bis zum Vollbild einer PML [94] kommen vor. Weitere neurologische Komplikationen sind multifokale demyelinisierende sensomotorische Polyneuropathien [95], sensible [82], motorische [82,96] und sensomotorische [97] Neuropathien, Engpasssyndrome [98], ein Haltetremor [70] (20-40 % der Behandelten [89]), seltener ein Intentionstremor [82], epileptische Anfälle [22,90] (1,5-6 % der Behandelten [82]), meist holozephale Kopfschmerzen (bis 37 % der Behandelten) [82], zerebellare Störungen mit Ataxie und Dysarthrie [82,90], visuelle Wahrnehmungsstörungen [82,90], pyramidale und extrapyramidale Störungen [82], intrakranielle Druckerhöhung, Retinopathien und Papillenischämie oder -schwellung [82,99], Optikusneuropathien [99,100], kortikale Blindheit und Aphasien [70,90,101]. Insgesamt entwickeln bis zu 40 % der behandelten Patienten meist leichte neurologische Symptome [82,89,93].…”
Section: Cyclosporinunclassified
“…Rare cases of CsA-associated demyelinating neuropathy have been reported ( Table 2). This review excludes reports confounded by: (a) co-therapy with other immunosuppressant drugs (e.g., muronomab or basiliximab) [99]; (b) suspicion of an etiopathogenic role of concurrent cytomegalovirus re-activation [99,100]; (c) evidence of solid organ rejection [101], or (d) electrodiagnostic evidence of a predominantly axonal variant of Guillain-Barré-like syndrome [93,102,103]. Neuropathy started within weeks of starting CsA, but also occurred years into maintenance treatment.…”
Section: Calcineurin Inhibitorsmentioning
confidence: 99%