Reversible Aggregation Control of Polyvinylpyrrolidone Capped Gold Nanoparticles as a Function of pH

Dhumale, Vinayak A.; Gangwar, Rajesh K.; Datar, Suwarna; Sharma, Rishi

doi:10.1166/mex.2012.1082

Cited by 72 publications

(39 citation statements)

References 35 publications

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“…In line with this, it was shown that aggregation/agglomeration of chemically synthesized citrate-capped AuNPs occurs immediately upon placing them in artificial saliva or serum-free cell culture media (RPMI or DMEM), whereas the agglomeration in the serumcontaining media was much slower [32,34,35]. These studies suggested that agglomeration/aggregation of citrate-capped AuNPs results from changes on the extension of capping by the citrate anions at the surface [36]. Although the increase in hydrodynamic size of USP-generated AuNPs in biological media was much smaller compared to those described for the chemically synthesized citrate-AuNPs, the expected size-dependent changes in the optical properties of USPgenerated AuC20 NPs due to agglomeration/aggregation do not allow their easy application in diagnostics.…”

Section: Properties Of Usp-generated Aunps In Cell Culturementioning

confidence: 70%

Morphology, Aggregation Properties, Cytocompatibility, and Anti-Inflammatory Potential of Citrate-Stabilized AuNPs Prepared by Modular Ultrasonic Spray Pyrolysis

Rudolf

Majeriź

Tomiź

et al. 2017

Journal of Nanomaterials

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Ultrasonic Spray Pyrolysis (USP) possesses a great potential for production of higher quantities of gold nanoparticles (AuNPs), thus overcoming the problem of batch-to-batch variations in their properties. Recently, we demonstrated that USP with an additional evaporation chamber (modular USP) led to a better size control of AuNPs. However, their morphology, stability, toxicity, and immunomodulatory properties have not been investigated completely. Here, two types of spherical AuNPs were produced by using different USP parameters, followed by their stabilization in Na-citrate solution. No significant changes in their size, agglomeration, andz-potential occurred 3 months after their initial production in citrate solution. However, the conditioning of AuNPs in serum-containing cell culture media for 24 h induced an increase in the AuNPs’ hydrodynamic size and a red shift in their Surface Plasmon Resonance, pointing to their instability in biological media. Cytocompatibility tests showed that the produced AuNPs were internalized by L929 cells and primary human monocytes and were not cytotoxic at the concentrations lower than 200 μg/mL, but they exhibited antiproliferative and anti-inflammatory effects, respectively. AuNPs reduced the percentage of CD14+CD16+but not CD14lowCD16+monocytes in vitro and reduced the expression of CD86, HLA-DR, TNF-α, and IL-12/IL-23 by these cells. These results indicate that the anti-inflammatory effects of citrate-capped AuNPs produced by modular USP could be beneficial for their application in the treatment of inflammatory conditions.

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Section: Properties Of Usp-generated Aunps In Cell Culturementioning

confidence: 70%

Morphology, Aggregation Properties, Cytocompatibility, and Anti-Inflammatory Potential of Citrate-Stabilized AuNPs Prepared by Modular Ultrasonic Spray Pyrolysis

Rudolf

Majeriź

Tomiź

et al. 2017

Journal of Nanomaterials

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“…The absorption band at 3400-3300 cm −1 for Hydroxy group was 1290 cm −1 , which exposed the symmetric stretching of the C-N or C-O bond [52]. In the case of PVP capped AuNPs, a shift of C-O stretching from 1650 cm −1 to 1630 cm −1 confirms the functionalisation of AuNPs with PVP via intermolecular hydrogen bonding [53]. Figure 3 shows the UV-vis spectra of AuNPs in collecting media from (i) C-HAuCl 4 and (ii) H-HAuCl 4 .…”

Section: Synthesis Of Aunpsmentioning

confidence: 99%

Low-cost synthesis of AuNPs through ultrasonic spray pyrolysis

Tiyyagura

Majerič

Anžel

et al. 2020

Mater. Res. Express

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The present research informs about the synthesis of gold nanoparticles (AuNPs) through Ultrasonic Spray Pyrolysis (USP), which were collected in ethanol with 0.1% Polyvinylpyrrolidone (PVP). Initially, the research focused on two precursors, where the first represented a homemade H-HAuCl 4 , completed in our own laboratory through the chlorine gas method by using HCl and KMnO 4 , and the second was the commercial C-HAuCl 4 , prepared by using Gold (III) chloride tetrahydrate powder and deionised water. The goal was to find any potential precursor differences and their influences on the later use for AuNPs synthesis through USP using almost the same parameters. In the first step of research it was determined that the H-HAuCl 4 precursor was similar to C-HAuCl 4 in chemical composition, surface tension and pH value. This finding represented the starting point for being able to use H-HAuCl 4 in the USP for AuNPs' synthesis. In the second step, AuNPs were synthesised from both types of precursors. Afterwards, characterisation of some functional properties by FTIR and UVvis techniques was done directly for H-and C-AuNPs in the collecting media. For SEM/EDX and TEM microscopy both types of H-and C-AuNPs were dried, and observation revealed that the morphology, shape and size distribution of dried AuNPs were very similar. Based on the performed laboratory research, it could be concluded that prepared H-AuNPs could represent a new and lowcost effective solution for future USP transfer onto the industrial level, not only in in the process itself, but also in the field of Low-cost Precursor Preparation.Abbreviations

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“…The FT‐IR spectra of PVP and PVP functionalized AgNPs are seen in Figure 1. The PVP spectrum shows its signature in the form of C=O (1660 cm −1 ) and C–N (1290 cm −1 ) . When PVP capped AgNPs, the peaks of C=O and C−N stretching forms shifted from 1660 cm −1 to the lower wave number of 1632 cm −1 and from 1290 cm −1 to 1252 cm −1 , respectively.…”

Section: Resultsmentioning

confidence: 99%

Electrochemical Determination of Ascorbic Acid Based on AgNPs/PVP‐Modified Glassy Carbon Electrode

Karaboduk

2019

ChemistrySelect

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The electrochemical determination of ascorbic acid was carried out at the surface of glassy carbon electrode (GCE) modified by silver nanoparticles (AgNPs):Polyvinylpyrrolidone (PVP). Nanocomposite was evaluated by fourier transform infrared spectroscopy, zeta potential, and X‐ray diffraction. Also, the surface morphologies of the developed electrode were investigated by scanning electron microscopy, and profilometer. The electrochemical performance of AgNPs/PVP/GCE was studied with cyclic voltammetry and electrochemical impedance spectroscopy measurements. The electrochemical studies demonstrated that the electrode had a large surface. Compared with the bare GCE, PVP/GCE, and AgNPs/GCE, the AgNPs/PVP‐modified GCE showed excellent performance for the electrochemical determination of ascorbic acid. At the optimized conditions of differential pulse voltammetry in pH 6.0 of phosphate buffer solution, the modified electrode allowed the determination of ascorbic acid on a potential of 0.54 V vs. Ag/AgCl. Under optimized conditions, the low detection limit of 0.047 μM and working range of 0.2‐1200 μM were obtained at the AgNPs/PVP/GCE. The AgNPs/PVP/GCE allowed to obtain highest peak current values at low concentrations. Moreover, the fabricated electrode also exhibited good repeatability, reproducibility, and stability. The developed electrode was successfully enforced for the analysis of ascorbic acid in banana, kiwi fruit, mango, and pineapple.

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Reversible Aggregation Control of Polyvinylpyrrolidone Capped Gold Nanoparticles as a Function of pH

Cited by 72 publications

References 35 publications

Morphology, Aggregation Properties, Cytocompatibility, and Anti-Inflammatory Potential of Citrate-Stabilized AuNPs Prepared by Modular Ultrasonic Spray Pyrolysis

Morphology, Aggregation Properties, Cytocompatibility, and Anti-Inflammatory Potential of Citrate-Stabilized AuNPs Prepared by Modular Ultrasonic Spray Pyrolysis

Low-cost synthesis of AuNPs through ultrasonic spray pyrolysis

Electrochemical Determination of Ascorbic Acid Based on AgNPs/PVP‐Modified Glassy Carbon Electrode

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