Reversible addition fragmentation chain transfer‐mediated bioconjugated amphiphilic graft‐block copolymer using dextran, poly (<i>N</i>‐isopropylacrylamide), and poly (vinyl acetate)

Karmakar, Puja Das; Shukla, Aparna; Maiti, Pralay; Chatterjee, Soumit; Pal, Sagar

doi:10.1002/app.50381

Cited by 6 publications

(5 citation statements)

References 52 publications

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“…RAFT polymerization is the most recent controlled/living radical polymerization method that has gained widespread acceptance due to its tolerance to a wide range of reaction conditions and functionality, making it ideal for polymerizing an almost infinite number of monomers [ 62 , 63 ]. RAFT was used to produce 2-methacryloxyethyl glucoside (glycopolymer) [ 64 ].…”

Section: Glycopolymer Synthesis Methodologiesmentioning

confidence: 99%

Glycopolymer-Based Materials: Synthesis, Properties, and Biosensing Applications

et al. 2022

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Glycopolymer materials have emerged as a significant biopolymer class that has piqued the scientific community's attention due to their potential applications. Recently, they have been found to be a unique synthetic biomaterial; glycopolymer materials have also been used for various applications, including direct therapeutic methods, medical adhesives, drug/gene delivery systems, and biosensor applications. Therefore, for the next stage of biomaterial research, it is essential to understand current breakthroughs in glycopolymer-based materials research. This review discusses the most widely utilized synthetic methodologies for glycopolymer-based materials, their properties based on structure–function interactions, and the significance of these materials in biosensing applications, among other topics. When creating glycopolymer materials, contemporary polymerization methods allow precise control over molecular weight, molecular weight distribution, chemical activity, and polymer architecture. This review concludes with a discussion of the challenges and complexities of glycopolymer-based biosensors, in addition to their potential applications in the future. Graphical Abstract

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Section: Glycopolymer Synthesis Methodologiesmentioning

confidence: 99%

Glycopolymer-Based Materials: Synthesis, Properties, and Biosensing Applications

et al. 2022

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“…The sol to gel phase change may occur either at lower critical solution temperature (LCST) or upper critical solution temperature. PNIPAM, 36 poly(N‐vinyl caprolactam) (pNVCL), 37 and so forth, are the most extensively used injectable hydrogels. In the literatures, kartogenin (KGN), PLGA, and PEG‐based thermo‐responsive injectable hydrogels showed excellent cartilage regeneration (CR) capability 38 .…”

Section: Formation Of Injectable Hydrogelmentioning

confidence: 99%

Advances in injectable hydrogel: Design, functional regulation, and biomedical applications

Karmakar,

Velu,

Vineeth Kumar

et al. 2023

Polymers for Advanced Techs

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Recently, injectable hydrogels have been considered smart materials and have been widely researched for their use as scaffolds. They resemble the extracellular matrix of native tissue and have the capability for homogeneous mixing with therapeutic agents. It can be implanted into living bodies with minimal invasiveness and usability for irregularly shaped sites. Such unique features make the injectable hydrogels as promising materials in tissue engineering, drug delivery system, and gene/protein delivery. This review article provides a comprehensive overview of the different mechanisms employed in the preparation of injectable hydrogel, as well as a detailed exploration of its applications in the biomedical field. Furthermore, the article highlights the critical importance of developing injectable hydrogels as market‐viable products, highlighting their potential impact in the field of regenerative medicine.

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“…In this context, injectable hydrogels can overcome the above drawbacks owing to their minimal invasive surgical procedures. − Earlier, different types of polymers (natural and synthetic polymers) have been utilized to prepare injectable hydrogels for tissue engineering applications due to their biocompatible nature. , However, synthetic polymers often require functional modifications for improvement in bioactivity . For example, Kumar et al prepared hydroxy apatite-functionalized chitin- and poly(caprolactone)-based injectable bone grafting hydrogels .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterizations of Bioactive Glass Nanoparticle-Incorporated Triblock Copolymeric Injectable Hydrogel for Bone Tissue Engineering

Pal

Karmakar

Vel

et al. 2023

ACS Appl. Bio Mater.

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Recently, injectable hydrogels have attracted much interest in tissue engineering (TE) applications because of their controlled flowability, adaptability, and easy handling properties. This work emphasizes the synthesis and characterizations of bioactive glass (BAG) nanoparticle-reinforced poly(ethylene glycol) (PEG)- and poly(N-vinylcarbazole) (pNVC)-based minimally invasive composite injectable hydrogel suitable for bone regeneration. First, the copolymer was synthesized from a combination of PEG and pNVC through reversible addition–fragmentation chain-transfer (RAFT) polymerization and nanocomposite hydrogel constructs were subsequently prepared by conjugating BAG particles at varying loading concentrations. Gel permeation chromatography (GPC) analysis confirmed the controlled nature of the polymer. Various physicochemical characterization results confirmed the successful synthesis of copolymer and nanocomposite hydrogels that showed good gelling and injectability properties. Our optimal nanocomposite hydrogel formulation showed excellent swelling properties in comparison to the copolymeric hydrogel due to the presence of hydrophilic BAG particles. The bone cell proliferation rate was found to be evidently higher in the nanocomposite hydrogel than in the copolymeric hydrogel. Moreover, the enhanced level of ALP activity and apatite mineralization for the nanocomposite in comparison to that for the copolymeric hydrogel indicates accelerated in vitro osteogenesis. Overall, our study findings indicate BAG particle-conjugated nanocomposite hydrogels can be used as promising grafting materials in orthopedic reconstructive surgeries complementary to conventional bone graft substitutes in cancellous bone defects due to their 3D porous framework, minimal invasiveness, and ability to form any desired shape to match irregular bone defects.

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Reversible addition fragmentation chain transfer‐mediated bioconjugated amphiphilic graft‐block copolymer using dextran, poly (N‐isopropylacrylamide), and poly (vinyl acetate)

Cited by 6 publications

References 52 publications

Glycopolymer-Based Materials: Synthesis, Properties, and Biosensing Applications

Glycopolymer-Based Materials: Synthesis, Properties, and Biosensing Applications

Advances in injectable hydrogel: Design, functional regulation, and biomedical applications

Synthesis and Characterizations of Bioactive Glass Nanoparticle-Incorporated Triblock Copolymeric Injectable Hydrogel for Bone Tissue Engineering

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