Reversibility of left ventricular asynergy by nitroglycerin in coronary artery disease

Reddy, Sudhakar P.; Curtiss, Edward I.; O'Toole, J D; Matthews, Robert G.; Salerni, Rosemarie; Leon, Donald F.; Shaver, James A.

doi:10.1016/0002-8703(75)90430-5

Cited by 21 publications

(2 citation statements)

References 21 publications

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“…Lesser improvement or deterioration of LVEF after TAVI in patients with incomplete revascularization may have different explanations including active coronary ischemia and non‐viable myocardium which are well established determinants of low LVEF as well as the fact that non‐revascularized CAD might result in a lesser degree of left ventricle hypertrophy regression and therefore diminished left ventricle reverse remodeling . Indeed, extensive left ventricular remodeling has been shown to be associated with impaired LVEF recovery despite the presence of viability .…”

Section: Discussionmentioning

confidence: 99%

Impact of coronary artery disease on left ventricular ejection fraction recovery following transcatheter aortic valve implantation

Freixa

Chan

Bonan

et al. 2014

Cathet Cardio Intervent

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Section: Discussionmentioning

confidence: 99%

Impact of coronary artery disease on left ventricular ejection fraction recovery following transcatheter aortic valve implantation

Freixa

Chan

Bonan

et al. 2014

Cathet Cardio Intervent

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“…Different markers of myocardial viability have been established: (a) functional improvement with post-extrasystolic potentiation (10,18,22,41) after the administration of nitroglycerin (8,9,23,31,42) or under catecholamine stimulation (1,10,26), (b) preserved enddiastolic wall thickness and systolic wall thickening (4,6,7,28,45,46,53) as well as (c) preserved F-18 deoxyglucose util-ization or mismatch between metabolism and perfusion on positron emission tomography (PET) (13,50,52).…”

Section: Zusammenfassungmentioning

confidence: 99%

Assessment of Myocardial Viability in Persistent Defects on Thallium-201 SPECT after Reinjection Using Gradient-Echo MRI

Morguet

Kogler²,

Schmitt³

et al. 1996

Nuklearmedizin

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SummaryThis prospective study assessed myocardial viability in 30 patients with coronary heart disease and persistent defects despite reinjection on TI-201 single-photon computed tomography (SPECT). In each patient, three observers graded TI-201 uptake in 7 left ventricular wall segments. Gradient-echo magnetic resonance imaging in the region of the persistent defect generated 12 to 16 short axis views representing a cardiac cycle. A total of 120 segments were analyzed. Mean end-diastolic wall thickness and systolic wall thickening (± SD) was 11.5 ± 2.7 mm and 5.8 ± 3.9 mm in 48 segments with normal TI-201 uptake, 10.1 ± 3.4 mm and 3.7 ± 3.1 mm in 31 with reversible lesions, 11.3 ± 2.8 mm and 3.3 ± 1.9 mm in 10 with mild persistent defects, 9.2 ± 2.9 mm and 3.2 ±2.2 mm in 15 with moderate persistent defects, 5.8 ± 1.7 mm and 1.3 ± 1.4 mm in 16 with severe persistent defects, respectively. Significant differences in mean end-diastolic wall thickness (p <0.0005) and systolic wall thickening (p <0.005) were found only between segments with severe persistent defects and all other groups, but not among the other groups. On follow-up in 11 patients after revascularization, 6 segments with mild-to-moderate persistent defects showed improvement in mean systolic wall thickening that was not seen in 6 other segments with severe persistent defects. These data indicate that most myocardial segments with mild and moderate persistent TI-201 defects after reinjection still contain viable tissue. Segments with severe persistent defects, however, represent predominantly nonviable myocardium without contractile function.

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Angiokardiographie

Simon¹,

Lins²

2000

Herzkatheter

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Reversibility of left ventricular asynergy by nitroglycerin in coronary artery disease

Cited by 21 publications

References 21 publications

Impact of coronary artery disease on left ventricular ejection fraction recovery following transcatheter aortic valve implantation

Impact of coronary artery disease on left ventricular ejection fraction recovery following transcatheter aortic valve implantation

Assessment of Myocardial Viability in Persistent Defects on Thallium-201 SPECT after Reinjection Using Gradient-Echo MRI

Angiokardiographie

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