Reversibility of Intrathoracic Lipotoxicity in Obesity After Bariatric Surgery

Roos, Albert de

doi:10.1016/j.jacc.2012.07.010

Cited by 2 publications

(1 citation statement)

References 25 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 17 , 18 Some authors have suggested that EAT adiposity plays a long-term sustained and protective effect in response to weight loss. 13 , 17 , 18 , 20 Epicardial fat may display cardioprotective properties and function as a buffer to protect the heart against exposure to excessively high levels of free fatty acids through local secretion of anti-inflammatory and anti-atherogenic adipokines. 7 An alternative explanation proposed by Gaborit et al 17 , 35 , 36 is that EAT is very sensitive to intermittent hypoxia, and sequent fibrosis may decreases its capacity to be modulated by weight loss through bariatric surgery or exercise.…”

Section: Discussionmentioning

confidence: 99%

Differential Effects of Bariatric Surgery Versus Exercise on Excessive Visceral Fat Deposits

et al. 2016

Medicine

View full text Add to dashboard Cite

The aim of the present study was to compare differential impacts of bariatric surgery and exercise-induced weight loss on excessive abdominal and cardiac fat deposition.Excessive fat accumulation around the heart may play an important role in the pathogenesis of cardiovascular disease. Recent evidences have suggested that bariatric surgery results in relatively less decrease in epicardial fat compared with abdominal visceral fat and paracardial fat.Sixty-four consecutive overweight or obese subjects were enrolled in the study. Clinical characteristics and metabolic profiles were recorded. The volumes of abdominal visceral adipose tissue (AVAT), abdominal subcutaneous adipose tissue (ASAT), epicardial (EAT), and paracardial adipose tissue (PAT) were measured by computed tomography in the bariatric surgery group (N = 25) and the exercise group (N = 39) at baseline and 3 months after intervention. Subjects in both the surgery and exercise groups showed significant reduction in body mass index (15.97%, 7.47%), AVAT (40.52%, 15.24%), ASAT (31.40, 17.34%), PAT (34.40%, 12.05%), and PAT + EAT (22.31%, 17.72%) (all P < 0.001) after intervention compared with baseline. In both the groups, the decrease in EAT was small compared with the other compartments (P < 0.01 in both groups). Compared with the exercise group, the surgery group had greater loss in abdominal and cardiac visceral adipose tissue (AVAT, ASAT, PAT, EAT+PAT) (P < 0.001), but lesser loss in EAT (P = 0.037).Compared with the exercise group, bariatric surgery results in significantly greater percentage loss of excessive fat deposits except for EAT. EAT, but not PAT, was relatively preserved despite weight reduction in both the groups. The physiological impact of persistent EAT deserves further investigation.

show abstract