Reversibility of Cadmium-Induced Health Effects in Rabbits

Abstract

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Increased Hepatic and Decreased Urinary Metallothionein in Rats after Cessation of Oral Cadmium Exposure

“…Human evidence, however, remains inconsistent: some authors [4][5][6] have observed that less severe renal tubular damage is reversible; others [7][8][9] have reported that, according to their experience, progression is the rule. In addition, there is only limited data available from animal experiments involving long-term oral exposure [10,11].Metallothioneins (MTs) have attracted much attention in studies of Cd toxicity since their isolation from the equine renal cortex more than 50 years ago (reviewed by Nordberg [12]). MTs comprise a family of low molecular mass (6-7 kDa) stress proteins incorporating a high content of cysteine and divalent metals.…”

“…Human evidence, however, remains inconsistent: some authors [4–6] have observed that less severe renal tubular damage is reversible; others [7–9] have reported that, according to their experience, progression is the rule. In addition, there is only limited data available from animal experiments involving long‐term oral exposure [10,11].…”