Reversibility From Delayed Hyperacute Rejection in Abo-Incompatible Renal Transplantation -Histopathological Findings of Renal Allograft Biopsy-

Sugiyama, Kentaro; Arai, Kenji; Aikawa, Atushi; Miyagi, Moriatsu; Ohara, Takahiro; Hasegawa, Akito; Hirayama, Naoki; Tajima, Eiji; Kawamura, T; Ogihara, Hideo; Hadano, T; Nakano, Toshiaki

doi:10.1097/00007890-200407271-00760

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“…Performing organ transplantation in ABO-incompatible cases continues to pose a significant challenge [ 7 ]. Even when the ABO antibody titre was “safe” on the day of transplantation, some ABOi recipients still experienced AMR or even hyper-acute rejection [ 8 , 9 ]. In contrast, some ABOi allografts survived without AMR when the posttransplant ABO antibody titre gradually increased to the preoperative level [ 10 , 11 ].…”

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confidence: 99%

Highly individual- and tissue-specific expression of glycoprotein group A and B blood antigens in the human kidney and liver

et al. 2021

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Background Currently, research on the quantitative distribution of ABO antigens in different organs and tissues remains limited. We aimed to examine the individual characteristics of blood group glycoprotein A and B antigen expression in human kidneys and livers. Methods We obtained human samples, including the renal artery, renal vein, renal tissue, hepatic artery, hepatic vein, portal vein, and hepatic tissue, from 24 deceased organ transplant donors. The expression of the blood group antigens glycoprotein A and B was analysed and compared by Western blotting. Results There was no significant difference in the expression between blood group glycoprotein A and B antigens at any of the seven sites (p > 0.05). The expression of both A and B antigens was highest in renal tissue and the portal vein and was lowest in the renal artery. A large difference in glycoprotein antigen expression was observed among various donors or different regions of the same individual. Univariate analysis revealed that glycoprotein A/B antigens were affected by the age and sex of donors and were significantly higher in males and in young people. Conclusions Our study found that blood group glycoprotein antigen expression showed certain trends and distinct distribution in the kidney, liver, and vessels among individuals and in different regions of the same individual, which may explain the different clinical outcomes of patients who received ABO-incompatible transplantation.

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