“…Such an idea was based on the assumption that augmenting glycogen in the liver must have a beneficial effect on the damaged liver. Knick and Emrich (1957) used tolbutamide, 3 g. daily for three to six weeks, in six cases of chronic hepatitis and six cases of liver cirrhosis without diabetes and reported increased appetite, decrease in serum bilirubin, marked restoration to normal of the serum proteins, and improvement in the bromsulphalein test. Improvement in bromsulphalein excretion was also reported in a diabetic patient by Pote, Anderson, and Cochran (1959).…”