Reversed Phase High Performance Liquid Chromatography Method Development and Validation for Simultaneous Estimation of Dicyclomine Hydrochloride, Paracetamol and Mefenamic Acid in Bulk and Tablet Dosage Form
Abstract:Objective: The objective of this study was to develop and validate a simple, precise and accurate reverse phase high performance liquid chromatographic method for simultaneous estimation of dicyclomine hydrochloride, paracetamol, and mefenamic acid from multicomponent tablet dosage form.
Methods:The optimized chromatographic separation was achieved using a stationary phase of hypersil gold ODS-C18 (250 × 4.6 mm i.d, 5 μm particle size) column and mobile phase of acetonitrile: Methanol: Potassium dihydrogen pho… Show more
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