Reversed-phase high performance liquid chromatography method for the determination of paraquat in whole blood

Zhang, Wuxiang; Su, Yicong; Shi, Jiangu; Zhang, Maosheng; Bide, WU; Chen, Shanying; Hu, Shirong; Rao, Zhiming; Zheng, Jianzhong

doi:10.1039/c4ay00227j

Cited by 12 publications

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“…For the accurate qualitative and quantitative concentration determination of paraquat and diquat, various analytical methods have been developed, including high-performance liquid chromatography–ultraviolet detection (HPLC–UV) [ 15 , 18 , 21 , 30 , 35 , 44 , 45 , 46 , 47 ], gas chromatography–mass spectrometry (GC–MS) [ 26 , 28 , 29 , 48 ], liquid chromatography–mass spectrometry (LC–MS/MS and LC–HRMS) [ 13 , 20 , 25 , 27 , 32 , 34 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ], capillary electrophoresis (CE) [ 56 , 57 , 58 ], surface-enhanced Raman spectroscopy (SERES) [ 59 , 60 , 61 ], and electrochemical methods [ 62 , 63 , 64 , 65 ], which we summarize in Figure 2 .…”

Section: Methodsmentioning

confidence: 99%

Paraquat and Diquat: Recent Updates on Their Pretreatment and Analysis Methods since 2010 in Biological Samples

Guo

Gao

2023

Molecules

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Paraquat (PQ) and diquat (DQ) are quaternary ammonium herbicides which have been used worldwide for controlling the growth of weeds on land and in water. However, PQ and DQ are well known to be toxic. PQ is especially toxic to humans. Moreover, there is no specific antidote for PQ poisoning. The main treatment for PQ poisoning is hemoperfusion to reduce the PQ concentration in blood. Therefore, it is essential to be able to detect PQ and DQ concentrations in biological samples. This critical review summarizes the articles published from 2010 to 2022 and can help researchers to understand the development of the sample treatment and analytical methods for the determination of PQ and DQ in various types of biological samples. The sample preparation includes liquid–liquid extraction, solid-phase extraction based on different novel materials, microextration methods, and other methods. Analytical methods for quantifying PQ and DQ, such as different chromatography and spectroscopy methods, electrochemical methods, and immunological methods, are illustrated and compared. We focus on the latest advances in PQ and DQ treatment and the application of new technologies for these analyses. In our opinion, tandem mass spectrometry is a good choice for the determination of PQ and DQ, due to its high sensitivity, high selectivity, and high accuracy. As far as we are concerned, the best LOD of 4 pg/mL for PQ in serum can be obtained.

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Section: Methodsmentioning

confidence: 99%

Paraquat and Diquat: Recent Updates on Their Pretreatment and Analysis Methods since 2010 in Biological Samples

Guo

Gao

2023

Molecules

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“…39 Jiang et al developed also a turn-on fluorogenic sensor for on-spot recognition of nerve agents mimicking DCP. 40 While there are various chromo-fluorogenic sensors developed so far for the recognition of DCP, detecting sarin in real threatening situations is still challenging. The heightened volatility of sarin makes it less amenable to capture by chromo-fluorophore moieties.…”

Section: Introductionmentioning

confidence: 99%

A highly selective chromo-fluorogenic probe for specific detection of sarin gas simulant diethylchlorophosphate in liquid and vapor phases

Sultana,

Mahato,

Ahamed

et al. 2024

Sens. Diagn.

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Pesticides (New Generation) and Related Compounds, Analysis of

Ccanccapa

Picó

2017

Encyclopedia of Analytical Chemistry

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This article presents an overview of analytical methods for the analysis of pesticide (new‐generation) and related compounds in the last 5 years, which updates the previous one. Pesticides included in this group display almost no change, but the evolution of analytical techniques is important. In general, new pesticides are now included in multiresidue methods with generic sample treatment methodologies being able to extract as many pesticide classes as possible. However, this article focuses not only on these common multiresidue methods but also on specific methodologies as single‐residue methods for the analysis of new‐generation pesticides. The most widely used detection technique for the determination of pesticides is mass spectrometry (MS) combined with gas chromatography (GC) and/or liquid chromatography (LC). However, the advances in immunoassays, biosensors and other techniques are also included. Finally, the future perspectives and the trends for pesticide residue analysis in food and environmental matrices are outlined.

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Reversed-phase high performance liquid chromatography method for the determination of paraquat in whole blood

Abstract: In this paper, a high performance liquid chromatography technique is established for quantification of paraquat in blood.

Cited by 12 publications

References 12 publications

Paraquat and Diquat: Recent Updates on Their Pretreatment and Analysis Methods since 2010 in Biological Samples

Paraquat and Diquat: Recent Updates on Their Pretreatment and Analysis Methods since 2010 in Biological Samples

A highly selective chromo-fluorogenic probe for specific detection of sarin gas simulant diethylchlorophosphate in liquid and vapor phases

Pesticides (New Generation) and Related Compounds, Analysis of

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