Reversed Lipid-Based Nanoparticles Dispersed in Iodized Oil for Transarterial Chemoembolization

Abstract

Transarterial chemoembolization (TACE) is a promising treatment for patients suffering from unresectable liver malignancy. A coarse emulsion of doxorubicin solution and iodized oil is widely used in clinical practice. However, this coarse emulsion lacks sufficient physical stability and can split into water and oil very quickly. Furthermore, most chemotherapeutics are quickly released into systematic circulation, causing serious adverse effects. In this study, we aimed to prepare reversed lipid-based nanoparticles (RLBNs) dispersed in iodized oil as nanocarriers for the delivery of hydrophilic chemotherapeutics. Unlike a simple mixture of drug solution and oil, RLBN is a homogenous system and possesses a hydrophobic nanostructure that has high dispersibility in oils. Hydrophilic chemotherapeutics were entrapped in the polar core juxtaposed by highly biocompatible lipid materials, such as egg phospholipids. A sustained drug-release profile was observed in both in vitro and in vivo pharmacokinetics studies. The results of computed tomography showed that RLBN–doxorubicin–iodized oil could remain in the tumor region for more than 14 days and that the growth of tumors was effectively suppressed. Thus, the current results suggest that RLBN is a promising drug delivery system and is compatible with TACE treatment.

In Vitro Cell Toxicity and Intracellular Uptake of Doxorubicin Exposed as a Solution or Liposomes: Implications for Treatment of Hepatocellular Carcinoma

“…This technique uses high-precision image guidance to locally dose the drug delivery system through the tumor’s artery, thereby creating a high local concentration in the tumor tissue, while reducing the systemic exposure and subsequent side effects [ 14 , 23 , 24 ]. Recently, there has been an increasing interest in combining TACE with therapeutic nanoparticles (TNPs) [ 25 ]. However, in order to develop safe and efficient strategies to reach intracellular targets, more insight is needed in regard to tumor cell net uptake of chemotherapeutics and their metabolites, as well as the cytotoxicity and intracellular exposure by chemotherapeutics as free drugs, or different parenteral formulations.…”

Biocompatible copper sulfide–based nanocomposites for artery interventional chemo-photothermal therapy of orthotropic hepatocellular carcinoma

“…Nano/micro material–based therapeutics have been widely used for embolic and drug-delivery systems via TAI injection, exhibiting high tumor cell uptake efficiency and less side-effect to surrounding normal tissues [ [15] , [16] , [17] ]. Recently, nanomaterials with photothermal conversion performance by near-infrared (NIR) irradiation have been widely utilized for photothermal therapy (PTT) of tumors [ [18] , [19] , [20] , [21] ].…”

Precision Embolism: Biocompatible Temperature‐Sensitive Hydrogels as Novel Embolic Materials for Both Mainstream and Peripheral Vessels

“…[ 6–9 ] In contrast, the liquid embolic reagents are capable to block peripheral vessels, but they always suffer from the rapid clearance with high recanalization probability (Scheme 1B). [ 10–13 ] In addition, ectopic embolism risk would arise due to the growing leakage of solid and liquid embolic reagents from embolism vessels.…”