Microfluidic
technology has aroused wide applications, including
analytical science, diagnostic technology, and micro-/nanofabrication.
However, bubbles in microfluidic channels always bring out adverse
impacts such as cell damage and device malfunction. To prevent bubble
formation, numerical simulation and experiments were integrated to
reveal the effect of the factors including the internal structure
of the channel, internal wettability, and liquid flow rate. On one
hand, the simulation results reveal that bubble formation can be prevented
by these mentioned factors, the weight of which can be provided by
a logistic regression model. In addition, the raised equilibrium equations
can efficiently explain the influence of these factors on bubble prevention.
On the other hand, the validity of the simulation was further verified
by the prevention of bubbles in the water-flowing microchannels. Therefore,
this work provides a promising strategy to prevent bubble formation
in microchannels, which has wide applications in microfluidic systems.